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DTPA folate

structure in first source

Also Known As:

(111In)DTPA-folate; DTPA-folate; diethylenetriaminepentaacetic acid-folate

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Pentetic Acid: 1751
      - DTPA folate: 7
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Pentetic Acid: 1751
        DTPA folate: 7
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        DTPA folate: 7

Experts

1.	Green, Mark A: 3 articles (10/2003 - 07/2002)
2.	Mathias, Carla J: 3 articles (10/2003 - 07/2002)
3.	Low, Philip S: 2 articles (10/2003 - 07/2002)
4.	Laforest, Richard: 1 article (10/2003)
5.	Lewis, Jason S: 1 article (10/2003)
6.	Lewis, Michael R: 1 article (10/2003)
7.	Reichert, David E: 1 article (10/2003)
8.	Sharp, Terry L: 1 article (10/2003)
9.	Snyder, Paul W: 1 article (10/2003)
10.	Waters, David J: 1 article (10/2003)

Related Diseases

1.

Neoplasms (Cancer)

07/01/2002 - "Intravenous administration of [99mTc]Tc(CO)(3)DTPA-folate to athymic mice bearing KB cell tumor xenografts resulted in 99mTc tumor uptake of 1.8 +/- 0.5 and 3.3 +/- 0.2%ID/g (n = 3) at 30 minutes and 4 hours post-injection, respectively. "
05/01/2003 - "We report here the initial clinical study of such an agent, (111)In-diethylenetriaminepentaacetic acid (DTPA)-folate, evaluated for diagnosis of ovarian malignancy. "
07/01/2002 - "[99mTc]Tc(CO)(3)DTPA-folate experienced high, folate-receptor-specific uptake in human KB tumor cells. "
09/01/1997 - "Design and synthesis of [111In]DTPA-folate for use as a tumor-targeted radiopharmaceutical."
09/01/1997 - "In a preliminary mouse imaging study, a folate receptor-positive KB cell tumor was readily visualized by gamma scintigraphy 1 h following intravenous administration of [111In]DTPA-folate (gamma)."

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Radiopharmaceuticals
3.	Technetium Tc 99m Pentetate
4.	Isotopes
5.	Pentetic Acid (DTPA)
6.	Acids

Related Therapies and Procedures

1.	Intravenous Administration