3- (difluoromethyl)- 1- (4- methoxyphenyl)- 5- (4- (methylsulfinyl)phenyl)pyrazole

09/01/1999 - "FR140423 did not inhibit yeast-induced paw edema. "
12/01/2001 - "We tested the inhibitory effects of FR140423 on paw edema and the formation of arachidonic acid metabolites in inflamed paws immunized with type II collagen. "
01/22/1999 - "Oral administration of FR140423 dose dependently reduced carrageenin-induced paw edema and adjuvant arthritis. "
09/15/2003 - "Oral administration of FR140423 (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole), a selective inhibitor of COX-2, showed a dose-dependent anti-inflammatory effect in mouse CIA with ED(50) value of 0.20mg/kg. Indomethacin, a non-selective inhibitor of COX, also inhibited paw edema in this arthritic model. "

09/01/1999 - "The profile of FR140423, a novel anti-inflammatory compound, in yeast-induced rat hyperalgesia."
10/16/2003 - "The present findings suggest that delta-opioid systems play a role in the rat anti-hyperalgesia produced by FR140423 for postoperative pain characterized by mechanical hyperalgesia."
10/16/2003 - "The action of FR140423 differs from the naloxonazine-reversible anti-hyperalgesia induced by morphine. "
10/16/2003 - "Furthermore, the delta-opioid receptor antagonist naltrindole (0.2 mg/kg) reversed anti-hyperalgesia induced by FR140423. "
10/16/2003 - "Oral administration of FR140423 at doses between 1 and 100 mg/kg after surgery dose dependently attenuated the punctate mechanical hyperalgesia caused by an incision of the plantar surface of the hind paw with an ED50 value of 59 mg/kg. The anti-hyperalgesic effect of systematically administered FR140423 was blocked by naloxone, a non-selective opioid receptor antagonist. "

05/01/2000 - "Anti-inflammatory effect of FR140423, a novel selective cyclo-oxygenase-2 inhibitor, in rat adjuvant arthritis without gastrointestinal side effects."
05/01/2000 - "We investigated the effect of FR140423 (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulphinyl)phen yl]pyrazole), a novel and selective cyclo-oxygenase (COX)-2 inhibitor, in rat adjuvant arthritis. "
01/22/1999 - "Oral administration of FR140423 dose dependently reduced carrageenin-induced paw edema and adjuvant arthritis. "

10/16/2003 - "We investigated the anti-hyperalgesic effect of FR140423, 3-(difluoromethyl)-1-(4-methoxyphenyl-5-[4-(methylsulfinyl)phenyl]pyrazole, in a rat model of postoperative pain. "
10/16/2003 - "The present findings suggest that delta-opioid systems play a role in the rat anti-hyperalgesia produced by FR140423 for postoperative pain characterized by mechanical hyperalgesia."
10/16/2003 - "Effect of systemic FR140423, a new analgesic compound, in a rat model of postoperative pain: contribution of delta-opioid receptors."

09/10/1999 - "Naloxone-induced jumping and diarrhea tests for morphine-like physical dependence of FR140423 gave negative results. "