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klotho protein

an aging suppressor gene; encodes a novel type I membrane protein of beta-glycosidase family; may functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor-1 (IGF1); mutation of the gene leads to a syndrome resembling human aging; named klotho, for one of the Fates, the Greek goddess who spins the thread of life
Also Known As:
KL protein, human; KL protein, mouse; klotho protein, human; klotho protein, mouse; klotho protein, rat
Networked: 35 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kuro-o, Makoto: 4 articles (01/2012 - 12/2007)
2. Yang, Wei: 2 articles (01/2015 - 01/2014)
3. Lang, Florian: 2 articles (01/2014 - 12/2013)
4. Kashihara, Naoki: 2 articles (12/2012 - 04/2011)
5. Nagasu, Hajime: 2 articles (12/2012 - 04/2011)
6. Satoh, Minoru: 2 articles (12/2012 - 04/2011)
7. Shiizaki, Kazuhiro: 2 articles (01/2012 - 03/2011)
8. Wu, Can: 1 article (12/2015)
9. Ma, Xiaoyu: 1 article (12/2015)
10. Shao, Ying: 1 article (12/2015)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Ureteral Obstruction
3. Kidney Calculi (Kidney Stone)
4. Neoplasms (Cancer)
5. Kidney Diseases (Kidney Disease)

Related Drugs and Biologics

1. Calcium
2. Insulin (Novolin)
3. Cystatin C
4. Lipocalins
5. Brain Natriuretic Peptide (Natrecor)
6. Gelatinases
7. Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)
8. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
9. Vitamin D
10. Rhodopsin (Visual Purple)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Nephrectomy