|1.||Conn, P Jeffrey: 4 articles (08/2015 - 08/2003)|
|2.||Hopkins, Corey R: 4 articles (08/2015 - 01/2009)|
|3.||Lindsley, Craig W: 4 articles (08/2015 - 01/2009)|
|4.||Marino, Michael J: 4 articles (02/2006 - 08/2003)|
|5.||Niswender, Colleen M: 3 articles (08/2015 - 01/2009)|
|6.||DiLella, Anthony G: 3 articles (10/2012 - 08/2003)|
|7.||Chang, Hee Jin: 3 articles (05/2005 - 06/2004)|
|8.||Yoo, Byong Chul: 3 articles (05/2005 - 06/2004)|
|9.||Park, Jae-Gahb: 3 articles (05/2005 - 06/2004)|
|10.||Snead, O C: 3 articles (01/2005 - 08/2000)|
|1.||Parkinson Disease (Parkinson's Disease)
06/01/2009 - "Preclinically in rodent models, mGluR4 activation has offered much promise as a novel treatment of Parkinson's disease. "
10/01/2012 - "The use of this novel tool molecule supports the proposal that activation of mGluR4 may be therapeutically useful in Parkinson's disease."
10/01/2012 - "A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease."
05/01/2012 - "Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature."
03/01/2010 - "mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455."
01/01/2012 - "These seizures are age-dependent, but data concerning the role of mGluR4 in immature brain is insufficient. "
02/19/2001 - "Disruption of the mGluR4 gene in mice results in impaired motor and spatial learning, and alterations in seizure susceptibility. "
01/01/2000 - "Our results suggest a potential role of mGluR4 in counteracting excitatory hippocampal activity and in modulating seizure-associated vulnerability of hippocampal neurons. "
11/01/1997 - "Upregulation of presynaptic mGluR4 in pup CA3 neurons could lead to reduced transmitter release from CA3 axons, including recurrent collaterals, thereby reducing vulnerability of neonatal CA3 neurons to seizure-induced damage. "
01/01/2011 - "It is proposed that mGluR1 antagonists and mGluR4/8 agonists show anticonvulsive effects on pentetrazol-induced kindled seizures. "
04/01/2005 - "To evaluate the use of various molecular markers as predictors of the response to CRT in rectal carcinoma, we investigated immunohistochemical expressions of p53, p21 WAF1/CIP1 , Bcl-2, Bax, Ki-67, Ku-70, and 2 new candidate markers (histone deacetylase 1 and metabotropic glutamate receptor 4) in pretreatment biopsy samples of 130 rectal carcinomas. "
05/01/2005 - "In the corresponding malignant tissues, mGluR4 expression was frequently identified in colorectal carcinoma (68%), followed by malignant melanoma, laryngeal carcinoma, and breast carcinomas. "
10/25/2015 - "This study aims to detect the expression of metabotropic glutamate receptors (mGluRs) in lung carcinoma A549 cells, and to investigate the effects of mGluR8 and mGluR4 activation on the growth of A549 cells in vitro. "
|4.||Schizophrenia (Dementia Praecox)
06/01/2001 - "Thus, this study did not provide evidence for the contribution of the mGluR4 gene to schizophrenia in the Japanese."
06/01/2001 - "There was no statistically significant association between any mGluR4 gene polymorphism and schizophrenia. "
06/01/2001 - "We searched for mutations in the exons of the metabotropic glutamate receptor mGluR4 (GRM4) gene on human chromosome 6p21.3 and evaluated associations between these polymorphisms with schizophrenia in Japanese patients. "
06/01/2001 - "Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia."
08/01/2013 - "Changes in paired-pulse facilitation that became overt in the presence of the GABAA antagonist picrotoxin indicated a function of mGluR4 in maintaining the excitation/inhibition balance, which is of crucial importance for information processing in the brain and the deterioration of these processes in neuropsychological disorders such as autism, epilepsy and schizophrenia. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
05/01/2005 - "In this study, we evaluated the nonneural expression of mGluR4 and clarified the existence of mGluR4 in normal colon epithelium and colorectal carcinomas. "
05/01/2005 - "Our results suggest that mGluR4 signaling may play a role in colorectal carcinomas and that overexpression of mGluR4 is associated with poor prognosis."
05/01/2005 - "Expression of mGluR4 was detected in 131 (54%) of 241 colorectal carcinomas and 12 (5%) cases among them showed overexpression in their cytoplasms. "
05/01/2005 - "In addition, 241 cases of colorectal carcinomas were examined and correlations between mGluR4 expression and various clinicopathologic parameters were then statistically analyzed. "
05/01/2005 - "Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance."
|1.||Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
|2.||metabotropic glutamate receptor type 1
|3.||metabotropic glutamate receptor 8
|4.||metabotropic glutamate receptor 2
|5.||metabotropic glutamate receptor 5
|8.||metabotropic glutamate receptor 4
|9.||Messenger RNA (mRNA)
|10.||metabotropic glutamate receptor 7
|2.||Palliative Care (Palliative Medicine)