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methyl-beta-cyclodextrin

structure in first source
Also Known As:
MEBCD cpd; beta-MCD; beta-methylcyclodextrin; methyl beta-cyclodextrin
Networked: 72 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Herrler, Georg: 3 articles (11/2008 - 04/2007)
2. Damonte, Elsa B: 2 articles (06/2013 - 10/2009)
3. Glende, Joerg: 2 articles (11/2008 - 11/2008)
4. Schwegmann-Wessels, Christel: 2 articles (11/2008 - 11/2008)
5. Zeidan, Asad: 2 articles (01/2008 - 09/2003)
6. Insel, Paul A: 2 articles (01/2008 - 07/2006)
7. Roth, David M: 2 articles (01/2008 - 07/2006)
8. Patel, Hemal H: 2 articles (01/2008 - 07/2006)
9. Bari, Monica: 2 articles (10/2006 - 04/2005)
10. Fezza, Filomena: 2 articles (10/2006 - 04/2005)

Related Diseases

1. Infection
2. Breast Neoplasms (Breast Cancer)
3. Insulin Resistance
4. Neoplasms (Cancer)
5. Carcinoma (Carcinomatosis)
02/01/2006 - "By analysing L1 (CD171) and CD44 in ovarian carcinoma cells, we show in the present paper that the cleavage induced by ionomycin, APMA (4-aminophenylmercuric acetate) or MCD (methyl-beta-cyclodextrin) is initiated in an endosomal compartment that is subsequently released in the form of exosomes. "
11/01/1998 - "The anti-tumour activity of methyl-beta-cyclodextrin (MEBCD), a cyclic oligosaccharide known for its interaction with the plasma membrane, was investigated in vitro and in vivo and compared with that of doxorubicin (DOX) in the human tumour models MCF7 breast carcinoma and A2780 ovarian carcinoma. "
01/01/2010 - "To investigate whether cholesterol could regulate uPAR and MMP-9 in breast carcinoma, we used MβCD (methyl beta cyclodextrin, which extracts cholesterol from lipid rafts) to disrupt lipid rafts and studied its effect on breast cancer cell migration, invasion, angiogenesis and signaling. "
01/01/2012 - "To determine if these benefits are a direct result of the cholesterol-lowering effects of statins or a result of secondary, protein transcription effects, the impacts of pravastatin and a cholesterol sequestrating agent methyl-beta-cyclodextrin (MbetaCD) on mRNA expression in the breast cancer cell MDA-MB-231 and the lung carcinoma cell Calu-1 have been compared by microarray techniques. "
04/01/2005 - "In the present study, it has been demonstrated that in the presence of a low (0.1%, w/v) concentration of fatty acid-free bovine serum albumin, a temperature-dependent and saturable (K(m) approximately 1 microM) uptake of anandamide into P19 embryonic carcinoma cells can be demonstrated using an incubation time of 4 min. Under these conditions, the uptake of anandamide at 4 degrees C is low at a substrate concentration of 100 nM. The uptake at 37 degrees C was not significantly reduced following treatment of the cells with either methyl-beta-cyclodextrin (50 microM) or mevinolin (1 microM), but was reduced by the FAAH inhibitor URB597 (1 microM) and inhibited by the transport inhibitor cum FAAH substrate AM404 with an IC(50) value of 12 microM. "

Related Drugs and Biologics

1. Cholesterol
2. Fluorouracil (Carac)
3. Insulin (Novolin)
4. Nystatin (Mycostatin)
5. Filipin (Filipin III)
6. Doxorubicin (Adriamycin)
7. Lovastatin (Mevacor)
8. anandamide (arachidonylethanolamide)
9. Amyloid Precursor Protein Secretases (beta-Secretase)
10. Bovine Serum Albumin

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Intravesical Administration