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B 1086

inhibits p21(ras) farnesyltransferase; methyl ester of B-956

Also Known As:

B-1086

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Methionine: 6648
      - B 1086: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Aklilu, F: 1 article (03/2000)
2.	Gladu, J: 1 article (03/2000)
3.	Goltzman, D: 1 article (03/2000)
4.	Rabbani, S A: 1 article (03/2000)

Related Diseases

1.

Neoplasms (Cancer)

10/15/1997 - "Treatment in vivo of BALB/c/nu/nu mice bearing Ras-3T3 tumors with B-1086 resulted in a significant inhibition in tumor growth. "
10/15/1997 - "We used this system to evaluate the effect of a potent inhibitor of Ras processing, B-1086, on cell growth, PTHRP production, plasma calcium, and tumor growth. "
03/15/2000 - "administration of B-1086 (50-100 mg/kg/day) into H-500 tumor-bearing male Fischer rats resulted in a dose-dependent reduction in tumor volume, serum calcium, plasma PTHRP, and tumoral PTHRP mRNA expression. "

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