|1.||Briggs, Michael D: 8 articles (01/2015 - 12/2005)|
|2.||Wagener, Raimund: 7 articles (03/2011 - 02/2004)|
|3.||Paulsson, Mats: 6 articles (03/2011 - 02/2004)|
|4.||Boot-Handford, Raymond P: 5 articles (01/2015 - 07/2007)|
|5.||Chen, Qian: 5 articles (12/2014 - 08/2006)|
|6.||Thornton, David J: 4 articles (05/2012 - 07/2007)|
|7.||Jayasuriya, Chathuraka T: 3 articles (12/2014 - 01/2012)|
|8.||Fresquet, Maryline: 3 articles (12/2013 - 11/2007)|
|9.||Bell, Peter A: 3 articles (12/2013 - 11/2010)|
|10.||Zaucke, Frank: 3 articles (05/2013 - 05/2008)|
|1.||Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
01/01/2014 - "Studies have shown that mutations in the matrilin-3 gene (MATN3) are associated with multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). "
12/20/2013 - "Mutant matrilin-3 (V194D) forms non-native disulphide bonded aggregates in the rER of chondrocytes from cell and mouse models of multiple epiphyseal dysplasia (MED). "
11/01/2010 - "Multiple epiphyseal dysplasia (MED) can result from mutations in matrilin-3, a structural protein of the cartilage extracellular matrix. "
11/01/2010 - "An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia."
01/01/2008 - "Mutations in the vWF A domain of matrilin-3 cause multiple epiphyseal dysplasia (MED), however the pathological mechanism remains to be determined. "
01/01/2012 - "Deletion or mutation of the gene encoding the cartilage extracellular matrix (ECM) protein matrilin-3 (MATN3) results in the early onset of osteoarthritis (OA), suggesting chondroprotective properties of MATN3. "
01/01/2012 - "The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). "
03/01/2010 - "We have previously shown that the mutations p.R116W and p.C299S, associated with MED and SEMD, respectively, cause retention of matrilin-3 within the endoplasmic reticulum of primary chondrocytes, while the mutation associated with osteoarthritis, p.T298M, does not hinder secretion. "
03/01/2010 - "Mutations in matrilin-3 have been associated with common skeletal diseases like osteoarthritis as well as with the rare chondrodysplasias MED and SEMD. "
11/19/2009 - "Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes."
12/12/2014 - "Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist."
01/01/2014 - "Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells."
08/01/2006 - "Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis."
|4.||Intervertebral Disk Degeneration
08/01/2006 - "Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand."
03/01/2011 - "In contrast, a mutation in an EGF domain of matrilin-3 that is associated with hand osteoarthritis and disc degeneration does not interfere with secretion but instead with extracellular assembly of matrix structures. "
07/15/2007 - "One such disorder, multiple epiphyseal dysplasia (MED), is characterized by mild dwarfism and early-onset osteoarthritis and can result from mutations in the gene encoding matrilin-3 (MATN3). "
01/01/2013 - "Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are skeletal disorders resulting from mutations in COMP, matrilin-3 or collagen IX and are characterised by short-limbed dwarfism and premature osteoarthritis. "
|2.||cartilage matrix protein
|3.||von Willebrand Factor
|4.||Epidermal Growth Factor (EGF)
|9.||Staphylococcal Protein A (A, Protein)