NK 109

10/01/1996 - "In the present study, NK109 treatment induced DNA fragmentation and a rise in the level of cytoplasmic nucleosomes, which are markers of apoptosis, in human small-cell lung carcinoma SBC-3 cells. "

11/10/2020 - "NK109 treatment mitigated K1-induced colitis and gut dysbiosis. "
02/03/2023 - "These findings suggest that dementia can fluctuate the gut microbiota composition and NK109 and its supplement NS can alleviate CI with systemic inflammation by inducing BDNF expression and suppressing NF-κB activation and gut microbiota dysbiosis."

11/10/2020 - "Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. "
11/10/2020 - "Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. "
02/03/2023 - "Lactobacillus gasseri NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition."

07/01/2005 - "The synthetic compound NK109 shows anti-tumor effects against a number of human cancer cell lines. "
07/01/2005 - "Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP."
07/01/2005 - "Our results show that the anti-tumor activity of NK109 stems from interactions with multiple protein targets."
07/01/2005 - "The mechanism of action is thought to involve the inhibition of DNA topoisomerase II. However, NK109 also exhibits potent anti-tumor activities against doxorubicin-, cisplatin- and etoposide-resistant human cell lines. "
10/01/1996 - "2,3-(Methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phenanthr idinium hydrogensulfate dihydrate, called NK109, is a benzo[c]phenanthridine derivative, which inhibits DNA topoisomerase II activity by stabilizing the DNA-enzyme-drug complex, and shows strong growth-inhibitory effects on several human cancer cells. "

02/03/2023 - "These findings suggest that dementia can fluctuate the gut microbiota composition and NK109 and its supplement NS can alleviate CI with systemic inflammation by inducing BDNF expression and suppressing NF-κB activation and gut microbiota dysbiosis."