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M-protease

highly alkaline resistant subtilisin-family serine protease from Bacillus; amino acid sequence in first source

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Subtilisins: 71
        M-protease: 3
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Subtilisins: 71
        M-protease: 3

Experts

1.	Carnaval, Thiago: 1 article (04/2022)
2.	Fernández-Nistal, Alonso: 1 article (04/2022)
3.	Giol, Jordi: 1 article (04/2022)
4.	ICAT-COVID team: 1 article (04/2022)
5.	Lleonart, Ramon: 1 article (04/2022)
6.	Malchair, Pierre: 1 article (04/2022)
7.	Montoto, Carmen: 1 article (04/2022)
8.	Otero, Aurema: 1 article (04/2022)
9.	Solanich, Xavier: 1 article (04/2022)
10.	Sánchez-Gabriel, Ana: 1 article (04/2022)

Related Diseases

1.	Hereditary Angioedemas 04/12/2022 - "Icatibant, a bradykinin type 2 receptor antagonist with proven effectiveness and safety against hereditary angioedema attacks, may be beneficial for COVID-19 patients by inhibiting bradykinin's action on endothelial cells and by inhibiting the SARS-CoV-2 M protease. "
2.	COVID-19 04/12/2022 - "Icatibant, a bradykinin type 2 receptor antagonist with proven effectiveness and safety against hereditary angioedema attacks, may be beneficial for COVID-19 patients by inhibiting bradykinin's action on endothelial cells and by inhibiting the SARS-CoV-2 M protease. "
3.	Chronic Disease (Chronic Diseases) 10/01/1983 - "Study of protease inhibitor function in patients suffering from acute or chronic illness suggested that in these patients their plasma becomes immunosuppressive due to inadequate handling of protease, resulting in alpha 2 M-protease complexes or inhibitory peptides persisting in the circulation. "
4.	Infections 10/30/1983 - "The enzyme denoted M protease was heat labile, was inhibited by the serine protease inhibitor phenylmethylsulfonyl fluoride, and its accumulation, which commenced between 2 and 3 hr after infection, required protein synthesis. "

Related Drugs and Biologics

1.	Bradykinin B2 Receptor
2.	Bradykinin
3.	icatibant
4.	Protease Inhibitors (Protease Inhibitor)
5.	Peptides (Polypeptides)
6.	Peptide Hydrolases (Proteases)
7.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
8.	Proteins (Proteins, Gene)
9.	Phenylmethylsulfonyl Fluoride
10.	Enzymes