aloxistatin

a membrane-permeable cysteine protease inhibitor

Also Known As:

(2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester; E64d inhibitor; EP 453; EP-453; epoxysuccinyl-leucylamide(3-methyl)butane ethyl ester; ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate; ethyl 3-(3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate; ethyl epoxysuccinyl-leucylamido-3-methylbutane; loxistatin; loxistatin, (2S-(2alpha,3beta(R*)))-isomer; protease inhibitor E64d

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Leucine: 6718
      - aloxistatin: 5
  - Essential Amino Acids: 1152
    - Leucine: 6718
      - aloxistatin: 5

Experts

1.	Liu, Jian: 2 articles (01/2022 - 08/2004)
2.	Guo, Qinglong: 1 article (01/2022)
3.	Guo, Yongjian: 1 article (01/2022)
4.	Li, Sichan: 1 article (01/2022)
5.	Sun, Yuening: 1 article (01/2022)
6.	Wang, Jubo: 1 article (01/2022)
7.	Wei, Libin: 1 article (01/2022)
8.	Xu, Ye: 1 article (01/2022)
9.	Yao, Jingyue: 1 article (01/2022)
10.	Choi, Soo-Young: 1 article (12/2019)

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy) 08/01/1990 - "Loxistatin is a possible therapeutic agent of muscular dystrophy. " 07/01/1992 - "Bestatin and Loxistatin, protease inhibitors, showed definite improvement on dystrophic mice or hamsters, animal models of muscular dystrophy. "
2.	Atherosclerosis 08/01/2004 - "The cysteinyl protease inhibitor E64d limits this increased elastolysis, indicating involvement of cysteine proteases in elastin degradation during atherogenesis. "
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 12/01/2019 - ": ACTB/β-actin: actin beta; ADM: adrenomedullin; AMBRA1: autophagy and beclin 1 regulator 1; AMPK: AMP-activated protein kinase; ANXA5: annexin A5; CP: cytogenetic response; CML: chronic myeloid leukemia; CUL3: cullin 3; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GCA: grancalcin; Dx: at diagnosis; E-64-d: (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester; IMres: Imatinib resistance; KLHL20: Kelch-like protein 20; LRMP: lymphoid-restricted membrane protein; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MMR: major molecular response; NH4Cl: ammonium chloride; PBMCs: peripheral blood mononuclear cells; PTPRC: protein tyrosine phosphatase, receptor type, C; SQSTM1/p62: sequestosome 1; SYK: spleen associated tyrosine kinase; TAP1: transporter 1, ATP binding cassette subfamily B member; TKIs: ABL-specific tyrosine kinase inhibitors; TLR9: toll- like receptor 9; TRAF6: TNF receptor associated factor 6; ULK1: unc-51 like autophagy activating kinase 1."
4.	Neoplasms (Cancer) 01/01/2022 - ": BNIP3: BCL2 interacting protein 3; CCCP: carbonyl cyanide p-trichloromethoxy-phenylhydrazone; CDK9: cyclin dependent kinase 9; CHX: cycloheximide; CQ, chloroquine; DFP: deferiprone; DOX: doxorubicin; EBSS: Earle's balanced salt solution; E64d: aloxistatin; FOXO3: forkhead box O3; HCC: hepatocellular carcinoma; HepG2/ADR: adriamycin-resistant HepG2 cells; MMP: mitochondrial membrane potential; mito-Keima: mitochondria-targeted and pH-sensitive fluorescent protein; MitoSOX: mitochondrial reactive oxygen species; OA: oroxylin A; PB: phosphate buffer; PDX: patient-derived tumor xenograft; PINK1: PTEN induced kinase 1; POLR2A: RNA polymerase II subunit A; p-POLR2A-S2: Ser2 phosphorylation of RNA polymerase II subunit A; PRKN: parkin RBR E3 ubiquitin protein ligase; SIRT1: sirtuin 1."
5.	Necrosis 08/01/1990 - "A single oral administration of loxistatin to male rats caused focal necrosis of the liver with inflammatory cell infiltration. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cysteine Proteases (Cysteine Protease)
3.	Sirtuin 1
4.	AMP-Activated Protein Kinases
5.	Adrenomedullin
6.	Toll-Like Receptor 9
7.	TNF Receptor-Associated Factor 6 (TRAF6)
8.	Cullin Proteins (Cullins)
9.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
10.	Cyclin-Dependent Kinase 9

Related Therapies and Procedures

1.	Oral Administration