|1.||Kastner, Daniel L: 11 articles (03/2015 - 12/2002)|
|2.||Chae, Jae Jin: 8 articles (03/2015 - 12/2002)|
|3.||Núñez, Gabriel: 8 articles (03/2015 - 02/2003)|
|4.||Taniguchi, Shun'ichiro: 7 articles (11/2015 - 05/2002)|
|5.||Masters, Seth L: 7 articles (03/2015 - 01/2006)|
|6.||Sagara, Junji: 6 articles (01/2015 - 05/2002)|
|7.||Masumoto, Junya: 6 articles (01/2014 - 05/2002)|
|8.||Aksentijevich, I: 6 articles (10/2011 - 06/2000)|
|9.||Aksentijevich, Ivona: 6 articles (11/2010 - 12/2002)|
|10.||Stehlik, Christian: 5 articles (10/2015 - 07/2003)|
01/01/2015 - "Recent studies have shown that mitochondrial production of ROS and inflammation may be closely linked through a redox sensor known as nod-like receptor pyrin domain-containing 3 (NLRP3). "
10/01/2014 - "The intriguing finding in this study was the induced activation of nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome with the increased IL-1β maturation in PFC of CUMS rats, suggesting a new grade of regulatory mechanism for IL-1β-related CNS inflammation. "
01/01/2007 - "This study confirmed that reduced expression of the MEFV gene is associated with inflammation and that it may be one of the pathogenic mechanisms of the attacks of inflammation in FMF patients, along with disease-associated variations in pyrin."
01/01/2015 - "Mutations of pyrin lead to uncontrolled attacks of inflammation, and subclinical inflammation continues during attack-free intervals. "
11/01/2014 - "Nod-like receptor pyrin domain containing 3 (NLRP3) is one such inflammasome involved in pancreatic inflammation. "
08/01/2015 - "It is prevalent among Mediterranean people and has been shown to be associated with mutations in the Mediterranean fever (MEFV) gene which, encodes pyrin a regulatory protein of the inflammasome. "
01/01/2015 - "Genetic mutations in the Mediterranean fever (MEFV) gene, encoding pyrin, influence the severity of RA, but the underlying mechanisms are not completely understood. "
11/01/2014 - "Mediterranean fever (MEFV) encodes the pyrin protein and is the causal disease gene in FMF. "
07/01/2013 - "The marenostrin-encoding fever (MEFV) gene, located on chromosome 16p13.3, is the only gene in which mutations are currently known to cause FMF. "
09/10/2012 - "The disease is associated with mutations in the Mediterranean fever (MEFV) gene, which encodes for the pyrin protein. "
06/01/2015 - "Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats."
06/01/2015 - "Recent studies indicated the involvement of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome in insulin resistance and a beneficial role of apelin in insulin resistance. "
11/01/2014 - "Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome, promotes insulin resistance, a precursor of type 2 diabetes. "
03/01/2012 - "Recent studies in rodents indicate that the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome and a proinflammatory shift in the T cell population in adipose tissue (AT) contribute to AT inflammation and insulin resistance. "
|4.||Familial Mediterranean Fever (Periodic Disease)
09/01/2015 - "The M680I and M694V mutations located in the B30.2 pyrin domain are responsible for the manifestation of the most common forms of Familial Mediterranean fever. "
01/01/2015 - "Familial Mediterranean fever is an autosomal recessive autoinflammatory disorder mainly affecting Mediterranean populations, which is associated with mutations of the MEFV gene that encodes pyrin. "
01/01/2015 - "The causative mutations for familial Mediterranean fever (FMF) are located in the MEFV gene, which encodes pyrin. "
12/01/2014 - "Immunological function of familial Mediterranean fever disease protein Pyrin."
09/11/2014 - "Mutations in the Pyrin-encoding gene, MEFV, cause a human autoinflammatory disease known as familial Mediterranean fever. "
09/01/2015 - "In response to enteric pathogen invasion, the Nod-like receptor pyrin domain containing (NLRP) inflammasome has been increasingly recognized as an important cytoplasmic sensor against microbial infection by activating caspase-1 and releasing IL-1β. "
06/15/2009 - "Similarly, the stable expression of pyrin in PMA-stimulated THP-1-derived macrophages induces caspase-1 activation, associated with increased IL-1beta release after infection with F. "
12/01/2005 - "A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection."
05/01/2014 - "This study identifies the first microbial molecule that activates pyrin, a mechanism by which infections may influence MS and a potential therapeutic target for immune disorders. "
01/07/2014 - "The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective role in intestinal inflammation and carcinogenesis, but the physiological function of this NLR during microbial infection is largely unexplored. "
|4.||STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
|8.||Anti-Bacterial Agents (Antibiotics)
|1.||Artificial Respiration (Mechanical Ventilation)
|4.||Renal Dialysis (Hemodialysis)