|1.||Bielawski, Jacek: 10 articles (11/2014 - 06/2007)|
|2.||Futerman, Anthony H: 9 articles (08/2015 - 01/2010)|
|3.||Pewzner-Jung, Yael: 7 articles (08/2015 - 08/2011)|
|4.||Ogretmen, Besim: 7 articles (01/2013 - 06/2007)|
|5.||Separovic, Duska: 6 articles (11/2014 - 03/2012)|
|6.||Kraveka, Jacqueline M: 5 articles (12/2015 - 06/2007)|
|7.||Haimovitz-Friedman, Adriana: 5 articles (11/2014 - 05/2005)|
|8.||Rahmaniyan, Mehrdad: 4 articles (12/2015 - 05/2012)|
|9.||Eberle, Max: 4 articles (10/2015 - 06/2012)|
|10.||Geisslinger, Gerd: 4 articles (10/2015 - 06/2012)|
04/17/2009 - "elegans from anoxia by HYL-2 ceramide synthase."
02/01/2005 - "However, the role of ceramide synthase in enhanced ceramide generation has not been previously examined in hypoxia-reoxygenation injury. "
02/01/2005 - "Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation."
02/01/2005 - "A specific inhibitor of ceramide synthase, fumonisin B1 (50 microM), suppressed hypoxia-reoxygenation-induced ceramide generation and provided protection against hypoxia-reoxygenation-induced EndoG release, DNA fragmentation, and cell death. "
02/01/2005 - "Taken together, our data suggest that hypoxia-reoxygenation results in an activation of ceramide synthase rather than sphingomyelinase and that ceramide synthase-dependent ceramide generation is a key modulator of EndoG-mediated cytotoxicity in hypoxia-reoxygenation injury to renal tubular epithelial cells."
10/03/2008 - "These studies define CEP-1 (the worm homolog of the tumor suppressor p53)-mediated accumulation of EGL-1 and ceramide synthase-mediated generation of ceramide through parallel pathways that integrate at mitochondrial membranes to regulate stress-induced apoptosis."
10/01/2012 - "We provide evidence that C(18)-pyridinium ceramide treatment or endogenous C(18)-ceramide generation by ceramide synthase 1 (CerS1) expression mediates autophagic cell death, independent of apoptosis in human cancer cells. "
07/01/2012 - "Inhibition of the de novo ceramide synthase pathway blocked drug-induced ceramide generation, PP2A activation and tumor cell killing. "
02/01/2012 - "Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells."
10/01/2010 - "By contrast, ceramide synthase 1-generated C(18)-ceramide has been shown to suppress tumor growth in various cancer models, both in situ and in vivo. "
02/01/2009 - "The aim of this study was to investigate the effects of fumonisin B1 (FB1), a specific inhibitor of ceramide synthase, on the development of nonseptic shock in mice caused by zymosan. "
07/01/1996 - "Tumor necrosis factor-alpha, anti-Fas antibody, anticancer drugs, radiation or heat shock induce apoptosis through generation of ceramide by activation of sphingomyelinase or ceramide synthase. "
01/01/1997 - "Perturbation of sphingolipid metabolism using synthetic and naturally occurring inhibitors of key enzymes of the biosynthetic pathways is aiding the characterization of these processes; for examples, inhibition of cerebroside synthase has indicated a role for ceramide in cellular stress responses including heat shock, and inhibition of ceramide synthase (by fumonisins) has revealed the role of disruption of sphingolipid metabolism in several animal diseases. "
|4.||Breast Neoplasms (Breast Cancer)
01/01/2010 - "We now study mRNA expression levels of the six ceramide synthase (CerS) genes in breast cancer tissue. "
01/01/2010 - "Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression."
08/01/2009 - "Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer."
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/01/2012 - "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells."
01/01/2013 - "Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells."
07/01/2012 - "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy."
11/01/2014 - "Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization."
12/01/2013 - "Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation."
|2.||DNA (Deoxyribonucleic Acid)
|3.||Messenger RNA (mRNA)
|6.||Sphingomyelin Phosphodiesterase (Sphingomyelinase)
|1.||Photochemotherapy (Photodynamic Therapy)
|2.||Heterologous Transplantation (Xenotransplantation)