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CD226 antigen

a signal-transducing molecule expressed on the majority of peripheral blood T lymphocytes & involved in their cytolytic function; recognized by the DX11 MAb
Also Known As:
CD226 antigen protein, human; CD226 antigen, mouse; CD226 protein, human; Cd226 protein, mouse; DNAM-1 protein, human; DNAM-1 protein, mouse; DNAX accessory molecule-1; PTA1 antigen; PTA1 antigen, human; TLiSA1 protein, human; platelet and T cell antigen 1; t lineage-specific activation antigen 1
Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ljunggren, Hans-Gustaf: 3 articles (05/2012 - 02/2007)
2. Santoni, Angela: 2 articles (01/2015 - 10/2009)
3. Colonna, Marco: 2 articles (01/2015 - 06/2013)
4. Chiocchia, Gilles: 2 articles (01/2015 - 06/2013)
5. Elhai, Muriel: 2 articles (01/2015 - 06/2013)
6. Soriani, Alessandra: 2 articles (01/2015 - 10/2009)
7. Allanore, Yannick: 2 articles (01/2015 - 06/2013)
8. Avouac, Jérôme: 2 articles (01/2015 - 06/2013)
9. Cippitelli, Marco: 2 articles (01/2015 - 10/2009)
10. Fionda, Cinzia: 2 articles (01/2015 - 10/2009)

Related Diseases

1. Neoplasms (Cancer)
10/01/2009 - "Recent findings indicate that the NK group 2D (NKG2D)- and DNAX accessory molecule-1 (DNAM-1)-activating receptors play a prominent role in tumor recognition and elimination by cytotoxic lymphocytes, suggesting that the levels of NKG2D and DNAM-1 ligand expression on tumor cells may be a critical factor to improve the immune response against cancer. "
01/01/2005 - "The aim of the present study was to evaluate the genetic status of three novel putative tumor suppressors, Cadh-7, DNAX accessory molecule-1 (Dnam-1) and suppressor of cytokine signaling (Socs6) on chromosome 18q and to correlate molecular results with patient survival and benefit from adjuvant chemotherapy. "
10/15/2009 - "The activating NK cell receptor DNAX accessory molecule-1 (DNAM-1) contributes to tumor immune surveillance and plays a crucial role in NK cell-mediated recognition of several types of human tumors, including ovarian carcinoma. "
01/01/2015 - "DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer responses; in this regard, combination therapies able to enhance the expression of DNAM-1 ligands on tumor cells are of therapeutic interest. "
05/01/2009 - "Here we show that human melanoma cell lines derived from LN metastases express ligands for natural cytotoxicity receptors (NCRs) and DNAX accessory molecule-1 (DNAM-1), two emerging NK cell receptors key for cancer cell recognition, but not NK group 2 member D (NKG2D). "
2. Melanoma (Melanoma, Malignant)
3. Hepatocellular Carcinoma (Hepatoma)
4. Carcinoma (Carcinomatosis)
5. Tuberculosis (Tuberculoses)

Related Drugs and Biologics

1. Ligands
2. Natural Killer Cell Receptors
3. Perforin
4. Granzymes (Granzyme)
5. Interferons
6. Carbon Monoxide
7. Antibodies
8. adhesion receptor
9. mica

Related Therapies and Procedures

1. Adjuvant Chemotherapy