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TDN 345
structure given in first source
Also Known As:
8-(4,4-bis(4-fluorophenyl)butyl)-3-(1,1-dimethylethyl)-4-methylene-1-oxa-3,8-diazaspiro(4,5)decan-2-one; TDN-345
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Spiro Compounds: 2
TDN 345: 2
Polycyclic Compounds: 6
Spiro Compounds: 2
TDN 345: 2
Related Diseases
1.
Cerebrovascular Disorders (Cerebrovascular Occlusion)
07/11/1997 - "
These results suggest that TDN-345 has therapeutic efficacy in the treatment of cerebrovascular disease.
"
2.
Stroke (Strokes)
07/11/1997 - "
The rate of LCGU decreased significantly in all the brain regions in SHRSP with stroke compared with Wistar-Kyoto (WKY) control rats, whereas the reduction in the rate of LCGU in SHRSP with stroke was prevented by TDN-345 treatment, especially in the sensorimotor cortex and locus coeruleus.
"
07/11/1997 - "
To determine the site of action of TDN-345 in the brain, the rate of LCGU in various brain regions in SHRSP with stroke was examined using a [14C]2-deoxy-D-glucose method.
"
07/11/1997 - "
The effects of TDN-345 on mortality and ischemic neurological deficit following transient global cerebral ischemia in Mongolian gerbils and also the rate of local cerebral glucose utilization (LCGU) in stroke-prone spontaneously hypertensive rats (SHRSP) with cerebrovascular lesions were investigated.
"
3.
Ischemia
07/11/1997 - "
In Mongolian gerbils, ischemia was produced by clamping the bilateral common carotid arteries for 15 min. TDN-345 (0.1-1.0 mg/kg) dose-dependently decreased the mortality and ischemic neurological deficit score when administered orally twice, 60 min before ischemia and 90 min after recirculation.
"
4.
Glioma (Gliomas)
11/07/1997 - "
The novel compound TDN-345 induces synthesis/secretion of nerve growth factor in C6-10A glioma cells.
"
11/07/1997 - "
A novel compound, TDN-345, not bearing catechol moiety, induced NGF synthesis/secretion in C6-10A glioma cells.
"
5.
Brain Ischemia (Cerebral Ischemia)
07/11/1997 - "
The effects of TDN-345 on mortality and ischemic neurological deficit following transient global cerebral ischemia in Mongolian gerbils and also the rate of local cerebral glucose utilization (LCGU) in stroke-prone spontaneously hypertensive rats (SHRSP) with cerebrovascular lesions were investigated.
"
Related Drugs and Biologics
1.
Nerve Growth Factor (NGF)
2.
Glucose (Dextrose)
3.
Deoxyglucose (2 Deoxy D glucose)
4.
catechol (pyrocatechol)