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fradafiban

structure given in first source

Also Known As:

5-((((4'-aminoiminomethyl)-(1,1'-biphenyl)-4-yl)oxy)methyl)-2-oxo-3-pyrrolidineacetic acid

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        fradafiban: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - fradafiban: 3

Experts

1.	Akkerhuis, K M: 1 article (04/2001)
2.	Baardman, T: 1 article (04/2001)
3.	Deckers, J W: 1 article (04/2001)
4.	Hoffmann, J: 1 article (04/2001)
5.	Peels, H O: 1 article (04/2001)
6.	Simoons, M L: 1 article (04/2001)
7.	Stibbe, J: 1 article (04/2001)
8.	Suryapranata, H: 1 article (04/2001)
9.	van Den Brand, M J: 1 article (04/2001)
10.	van Der Wieken, L R: 1 article (04/2001)

Related Diseases

1.	Stable Angina 04/01/2001 - "The present phase II study aimed to determine the dose of lefradafiban that provides 80% blockade of the glycoprotein IIb/IIIa receptors by fradafiban, and to study the pharmacodynamics and safety of different doses in patients with stable angina undergoing angioplasty. "
2.	Coronary Artery Disease (Coronary Atherosclerosis) 11/01/1997 - "The dose response to fradafiban and additional effects of aspirin were explored initially in patients with stable coronary artery disease. "
3.	Unstable Angina 10/01/1999 - "Citrated blood from 8 patients with unstable angina, randomised to receive oral lefradafiban (the oral prodrug of fradafiban) or placebo, was studied before and during treatment using WBSPC, PRP turbidimetry, impedance aggregometry and Rapid Platelet Function Assay (RPFA, Accumetrics). "

Related Drugs and Biologics

1.	lefradafiban
2.	Glycoproteins (Glycoprotein)
3.	Prodrugs
4.	Aspirin (Acetylsalicylic Acid)