DNA synthesome

a replication-competent multiprotein from human leukemia cell line HL-60; contains DNA polymerases alpha and delta, DNA primase, PCNA, replication factor C, replication protein A and DNA topoisomerases I and II

Also Known As:

Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hickey, Robert J: 3 articles (01/2016 - 07/2005)
2.	Malkas, Linda H: 3 articles (01/2016 - 07/2005)
3.	Gaimster, Hannah: 1 article (01/2022)
4.	Koh, Alan: 1 article (01/2022)
5.	Murray, Heath: 1 article (01/2022)
6.	Winterhalter, Charles: 1 article (01/2022)
7.	Li, Caroline M: 1 article (01/2016)
8.	Lingeman, Robert G: 1 article (01/2016)
9.	Miao, Yunan: 1 article (01/2016)
10.	Dai, Heqiao: 1 article (04/2009)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/1998 - "Recently, it has been shown that the multiprotein DNA replication complex (synthesome) from breast cancer cells has a significantly decreased replication fidelity compared to that of nonmalignant breast cells. " 01/01/1997 - "We have previously described the isolation and characterization of an intact multiprotein complex for DNA replication, designated the DNA synthesome, from human breast cancer cells and biopsied human breast tumor tissue. " 01/01/1996 - "The DNA synthesome purified from the breast cancer tissues fully supports SV40 DNA replication in vitro. " 01/01/1996 - "In addition, we successfully isolated the DNA synthesome from human breast tumor tissue as well as from xenografts from nude mice injected with the human breast cancer cell line MCF-7. " 01/01/2000 - "The purpose of this study was to further investigate the mechanism of action of ara-C using the DNA synthesome isolated from the human breast cancer cell line MDA MB-468. "
2.	Leukemia 06/01/1997 - "The purified DNA synthesome will not only allow the further study of the molecular mechanisms required to carry out human leukemia cell DNA replication, but may also provide a tool for eventually dissecting some of the regulatory controls of the cell's DNA synthetic machinery." 06/01/1997 - "In this report we describe, for the first time, the purification and characterization of a replication-competent multiprotein form of DNA polymerase (designated the DNA synthesome) from the human leukemia cell line (HL-60) using a series of centrifugation, ion-exchange chromatography and velocity sedimentation steps. " 12/01/1997 - "We previously identified and characterized the human leukemia (HL-60) cell DNA synthetic machinery as a multiprotein form of DNA polymerase, which was designated the DNA synthesome. " 06/01/1997 - "Since SV40 is extensively dependent on the host cell's DNA synthetic machinery for its own DNA replication, our results indicate that the isolated leukemia cell DNA synthesome may play a role not only in viral DNA synthesis but also in human leukemia cell DNA replication. " 06/01/1997 - "This result implies that all of the cellular activities required for large T-antigen-dependent in vitro SV40 DNA synthesis are present in the isolated human leukemia cell DNA synthesome. "
3.	Neoplasms (Cancer) 01/01/2016 - "The isolated native DNA synthesome can be of use in studying the mechanism by which mammalian DNA replication is carried-out and how anti-cancer drugs disrupt the DNA replication or repair process. " 07/01/2005 - "The data reported here characterize the human NB DNA synthesome for the first time and provide the groundwork for investigating whether the NB DNA synthesome contributes to faulty DNA replication and tumor pathogenesis for this childhood malignancy." 08/01/1998 - "The decrease in tumor cell replication fidelity was not due to an increased proliferative capacity of the tumor cells or an increase in the synthetic activity of their DNA synthesome. " 01/01/1996 - "The human breast cell DNA synthesome: its purification from tumor tissue and cell culture." 01/01/2000 - "Ara-C affects formation of cancer cell DNA synthesome replication intermediates."
4.	Chromosome Breakage 01/01/2022 - "Here we discuss techniques that can be used with live bacterial cells to analyze DNA replisome dynamics, double-strand chromosome breaks, and restart of repaired replication forks."
5.	Carcinoma (Carcinomatosis) 01/01/2000 - "An intact and fully functional multiprotein DNA replication complex (DNA synthesome) from human as well as from murine mammary carcinoma cells was first isolated and characterized in our laboratory. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Cytarabine (Cytosar-U)
3.	DNA-Directed DNA Polymerase (Polymerases, DNA)
4.	DNA synthesome
5.	Replication Protein C (Replication Factor C)
6.	Replication Protein A
7.	DNA Topoisomerases
8.	DNA Primase (Primase)
9.	Proliferating Cell Nuclear Antigen (PCNA)
10.	Proteins (Proteins, Gene)