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tracizoline

RN given for (R-(R*,R*))-2,3-dihydroxybutanedionate (1:1); ligand for imidazoline receptor; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - tracizoline: 3

Experts

1.	Li, Jun-Xu: 2 articles (03/2014 - 07/2012)
2.	Thorn, David A: 2 articles (03/2014 - 07/2012)
3.	Zhang, Yanan: 2 articles (03/2014 - 07/2012)
4.	García-Fuster, M Julia: 1 article (01/2021)
5.	Hernández-Hernández, Elena: 1 article (01/2021)
6.	Peng, Bi-Wen: 1 article (03/2014)
7.	Qiu, Yanyan: 1 article (03/2014)
8.	An, Xiao-Fei: 1 article (07/2012)
9.	Pigini, Maria: 1 article (07/2012)

Related Diseases

1.	Pain (Aches) 03/01/2014 - "The effects of morphine and I2 receptor ligands, 2-BFI, BU224, tracizoline and CR4056, 3.2-32 mg·kg(-1) , i.p., on hyperalgesia or affective pain (as measured by a place escape/avoidance paradigm) were studied in separate experiments. "
2.	Hypothermia 07/01/2012 - "KEY RESULTS All the selective I(2) receptor agonists examined (2-BFI, diphenyzoline, phenyzoline, CR4056, tracizoline, BU224 and S22687, 3.2-56 mg·kg(-1) , i.p.) dose-dependently and markedly decreased the rectal temperature (hypothermia) in rats, with varied duration of action. " 07/01/2012 - "Pharmacological mechanism of the observed hypothermia was studied by combining the I(2) receptor agonists (2-BFI, BU224, tracizoline and diphenyzoline) with imidazoline I(2 ) receptor/ α(2) adrenoceptor antagonist idazoxan, selective I(1) receptor antagonist efaroxan, α(2) adrenoceptor antagonist/5-HT(1A) receptor agonist yohimbine. "
3.	Hyperalgesia 03/01/2014 - "Morphine and the I2 receptor ligands (2-BFI, BU224 and tracizoline) all dose-dependently attenuated mechanical and thermal hyperalgesia in CFA-treated rats. " 03/01/2014 - "The effects of morphine and I2 receptor ligands, 2-BFI, BU224, tracizoline and CR4056, 3.2-32 mg·kg(-1) , i.p., on hyperalgesia or affective pain (as measured by a place escape/avoidance paradigm) were studied in separate experiments. "
4.	Body Weight (Weight, Body) 01/01/2021 - "At the dose selected, 2-BFI and tracizoline did not alter body weight or cognitive performance. "

Related Drugs and Biologics

1.	BU 224
2.	2-(2-benzofuranyl)-2-imidazoline
3.	CR4056
4.	Imidazolines
5.	Idazoxan
6.	Yohimbine (Yocon)
7.	Adrenergic Receptors (Adrenergic Receptor)
8.	Morphine (MS Contin)
9.	Ligands
10.	(5- (2- methylphenoxymethy)- 1,3- oxazolin- 2- yl) amine