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2B1 monoclonal antibody
a bispecific murine monoclonal antibody targeting c-erbB-2 and Fc gamma RIII; used in immunotherapy
Also Known As:
MAb 2B1; monoclonal antibody 2B1
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Serum Globulins: 553
Immunoglobulins: 30480
Antibodies: 133716
Monoclonal Antibodies: 56412
2B1 monoclonal antibody: 3
Bispecific Antibodies: 968
2B1 monoclonal antibody: 3
Immunoproteins: 43
Immunoglobulins: 30480
Antibodies: 133716
Monoclonal Antibodies: 56412
2B1 monoclonal antibody: 3
Bispecific Antibodies: 968
2B1 monoclonal antibody: 3
Globulins: 3062
Serum Globulins: 553
Immunoglobulins: 30480
Antibodies: 133716
Monoclonal Antibodies: 56412
2B1 monoclonal antibody: 3
Bispecific Antibodies: 968
2B1 monoclonal antibody: 3
Related Diseases
1.
Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
12/01/1995 - "
Specimens from diagnostic tissue biopsies were used as diseased skeletal muscle: polymyositis (PM), n = 13; Duchenne muscular dystrophy (DMD), n = 6. Frozen sections 8 microns thick were stained immunohistochemically for either cTnI or TnI (cardiac or skeletal) by using monoclonal antibodies (MAb) 2B1.9 (cTnI specific) or 3C5.10 (reactive with all TnI isoforms), respectively.
"
2.
Polymyositis
12/01/1995 - "
Specimens from diagnostic tissue biopsies were used as diseased skeletal muscle: polymyositis (PM), n = 13; Duchenne muscular dystrophy (DMD), n = 6. Frozen sections 8 microns thick were stained immunohistochemically for either cTnI or TnI (cardiac or skeletal) by using monoclonal antibodies (MAb) 2B1.9 (cTnI specific) or 3C5.10 (reactive with all TnI isoforms), respectively.
"
3.
Neoplasms (Cancer)
12/15/1992 - "
Bispecific murine monoclonal antibody 2B1, possessing dual specificity for the human c-erbB-2 protooncogene product and human Fc gamma receptor III (CD16) was evaluated for the ability to promote specific lysis of c-erbB-2-positive tumor cells in vitro.
"
4.
Carcinoma (Carcinomatosis)
11/01/1999 - "
Splenocytes from untreated and IL-2-treated hFcgammaRIIIA, hFcgammaRIIIB, and hFcgammaRIIIA/B mice exhibited enhanced in vitro cytotoxicity toward HER-2/neu-overexpressing SK-OV-3 human ovarian carcinoma cells when incubated with the murine bispecific mAb 2B1, which has specificity for HER-2/neu and hFcgammaRIII.
"
Related Drugs and Biologics
1.
Protein Isoforms (Isoforms)
2.
IgG Receptors (Fc gamma RI)
3.
Monoclonal Antibodies