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N-(4-hydroxyphenyl)arachidonylamide (AM404)

Also Known As:
AM404; AM 404; AM-404; N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide
Networked: 38 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Piomelli, D: 4 articles (03/2008 - 05/2000)
2. Fowler, Christopher J: 4 articles (10/2006 - 04/2003)
3. Calignano, A: 3 articles (03/2008 - 05/2000)
4. Di Marzo, Vincenzo: 3 articles (10/2006 - 03/2003)
5. Makriyannis, Alexandros: 2 articles (11/2014 - 03/2003)
6. Hasanein, Parisa: 2 articles (11/2009 - 10/2009)
7. La Rana, G: 2 articles (03/2008 - 06/2006)
8. Iacono, A: 2 articles (03/2008 - 06/2006)
9. Russo, R: 2 articles (03/2008 - 06/2006)
10. Meli, R: 2 articles (03/2008 - 06/2006)

Related Diseases

1. Hyperalgesia
2. Parkinsonian Disorders (Parkinsonism)
3. Pain (Aches)
4. Neuralgia (Stump Neuralgia)
5. Glioma (Gliomas)
04/01/2003 - "In the present study, AM404 and VDM 11 were found to reduce C6 glioma cell proliferation with IC(50) values of 4.9 and 2.7 microM, respectively. "
10/01/2006 - "It is concluded that AM404, VDM11, UCM707 and OMDM2 produce a rapid loss of C6 glioma cell viability over the same concentration range as is required for the inhibition of AEA uptake in vitro, albeit with a longer latency. "
04/01/2003 - "AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide."
10/01/2006 - "In this study, the effects of four commonly used acyl-based uptake inhibitors [N-(4-hydroxyphenyl)arachidonylamide (AM404), N-(4-hydroxy-2-methylphenyl) arachidonoyl amide (VDM11), (5Z,8Z,11Z,14Z)-N-(3-furanylmethyl)-5,8,11,14-eicosatetraenamide (UCM707) and (9Z)-N-[1-((R)-4-hydroxybenzyl)-2-hydroxyethyl]-9-octadecen-amide (OMDM2)] and the related compound arvanil on C6 glioma cell viability were investigated. "
05/10/2004 - "Recently, three compounds, UCM707 [N-(Fur-3-ylmethyl)arachidonamide], OMDM-1 and OMDM-2 [the 1'-(S)- and 1'-(R)-enantiomers of the 1'-4-hydroxybenzoyl analogue of oleoylethanolamide], selective for the uptake process, have been described and we have used these compounds, together with AM404 [(N-(4-hydroxyphenyl) arachidonoyl amide)] and VDM11 [(5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide]), with the initial aim of determining which mechanism of uptake predominates in C6 glioma and RBL-2H3 cells. "

Related Drugs and Biologics

1. Endocannabinoids (Endocannabinoid)
2. anandamide (arachidonylethanolamide)
3. Formaldehyde (Formol)
4. N- (3- furylmethyl)eicosa- 5,8,11,14- tetraenamide
5. Streptozocin (Streptozotocin)
6. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597)
7. Freund's Adjuvant
8. N- (2- methyl- 3- hydroxyphenyl)- 5,8,11,14- eicosatetraenamide
9. Bovine Serum Albumin
10. Lovastatin (Mevacor)

Related Therapies and Procedures

1. Ligation
2. Analgesia
3. Injections