JTV 506

structure given in first source; a potassium channel activator

Also Known As:

2,3-bis(methoxymethyl)-4-((1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)amino)-3-hydroxychroman-6-carbonitrile hemihydrate; JTV-506

Networked: 7 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromans: 3
        JTV 506: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromans: 3
        JTV 506: 7

Experts

1.	Makita, Tetsuji: 1 article (01/2004)
2.	Shibata, Osamu: 1 article (01/2004)
3.	Sumikawa, Koji: 1 article (01/2004)
4.	Tsutsumi, Yohsuke: 1 article (01/2004)
5.	Yamaguchi, Koji: 1 article (01/2004)
6.	Hu, J: 1 article (10/2000)
7.	Jia, D L: 1 article (10/2000)
8.	Qi, G X: 1 article (10/2000)
9.	Zeng, D Y: 1 article (10/2000)
10.	Zheng, X W: 1 article (10/2000)

Related Diseases

1.	Angina Pectoris 03/01/2000 - "These results suggest that JTV-506 may be useful in the treatment of angina pectoris." 03/01/1999 - "It is expected that JTV-506 might be useful in the treatment of coronary vasospasm in angina pectoris." 03/01/1997 - "These results suggest that the action of JTV-506 on hemodynamics is different from that of other vasodilators, including reference potassium channel openers, and that the profile of cardiovascular action of JTV-506 may be useful in the treatment of angina pectoris." 02/01/1998 - "Thus JTV-506 exerts a potent protective effect on angina pectoris models to an extent similar to those of levcromakalim, nicorandil, and nifedipine, whereas its action on systemic blood pressure is different from that of other vasodilators, including reference potassium channel openers. "
2.	Coronary Vasospasm (Coronary Artery Vasospasm) 03/01/1999 - "It is expected that JTV-506 might be useful in the treatment of coronary vasospasm in angina pectoris."
3.	Pulmonary Hypertension 01/01/2004 - "In the presence of MCT-induced pulmonary hypertension, JTV-506 may further attenuate pulmonary vascular tone through its direct action on endothelial cells, possibly by stimulating the endothelial release of NO." 01/01/2004 - "This study was designed to investigate the possibility that JTV-506, a new adenosine trisphoshate-sensitive potassium channel opener, may serve as a useful vasodilator in the treatment of pulmonary hypertension. "
4.	Myocardial Infarction 10/01/2000 - "[Effects of a novel KATP channel opener JTV-506 on myocardial infarct size of isolated rat heart]."
5.	Inflammation (Inflammations) 11/01/1999 - "Effects of an ATP-sensitive K+ channel activator, JTV-506, on dual asthmatic responses and airway inflammation after antigen inhalation challenge were investigated in asthma model of guinea pigs. "

Related Drugs and Biologics

1.	Potassium Channels (Potassium Channel)
2.	Vasodilator Agents (Vasodilators)
3.	Adenosine (Adenocard)
4.	KATP Channels
5.	Nicorandil (SG 75)
6.	Cromakalim (Levcromakalim)
7.	Nifedipine (Adalat)
8.	Antigens
9.	Adenosine Triphosphate (ATP)