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methyl 3,20- dioxo- 9- fluoro- 11,17,21- trihydroxy- 1,4- pregnadiene- 16- carboxylate

structure in first source

Also Known As:

FP16CM; methyl 9-fluoro-11,17,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16-carboxylate

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        methyl 3,20-dioxo-9-fluoro-11,17,21-trihydroxy-1,4-pregnadiene-16-carboxylate: 4

Experts

1.	Heiman, Ann S: 2 articles (01/2006 - 03/2002)
2.	Ko, Dong-Hoon: 2 articles (01/2006 - 03/2002)
3.	Lee, Henry Joung: 1 article (01/2006)
4.	Park, Kwan-Kyun: 1 article (01/2006)
5.	You, Zhengqing: 1 article (01/2006)
6.	Hudson, Charles E: 1 article (03/2002)
7.	Lee, Henry J: 1 article (03/2002)

Related Diseases

1.	Edema (Dropsy) 01/01/2006 - "Among those compounds tested, FP16CM showed the highest activities in receptor binding, NO inhibition and ear edema, these activities were comparable to those of prednisolone. " 03/01/2002 - "From these dose-response profiles, the following ID(50) values (nmol/ear resulting in a 50% reduction of edema) were calculated: prednisolone (Pred); 454, FP16CM; 255, 21-acetate (FP16CM-acetyl); 402, 21-propionate (FP16CM-propionyl); 474, 21-valerate (FP16CM-valeryl); 446 and 21-pivalate (FP16CM-pivalyl); 219 nmol. " 06/01/1997 - "From these dose-response profiles, the following ID50 values (nmol resulting in a 50% reduction of edema) were calculated: 817, 540, 266, and 67 for hydrocortisone (HC), prednisolone (P), FP16CM, and FP16CMAc, respectively. "
2.	Inflammation (Inflammations) 12/01/1998 - "In continuing efforts to synthesize potent, anti-inflammatory steroids devoid of systemic side effects, methyl 9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16 alpha-carboxylate (FP16CM) and its 21-acetate derivative (FP16CMAc) were recently synthesized and screened in animal models of inflammation. "

Related Drugs and Biologics

1.	Prednisolone (Predate)
2.	methyl 21- acetyloxy- 3,20- dioxo- 11,17- dihydroxy- 9- fluoro- 1,4- pregnadiene- 16- carboxylate
3.	Steroids
4.	Hydrocortisone (Cortisol)
5.	prednylidene (Pred)