Phosphofructokinase-2

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Also Known As:

Phosphofructokinase 2; 6-PF-2-K-Fru-2,6-P(2)ase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase; 6PF2K; ATP-D-Fructose-6-phosphate 2-phosphotransferase; F Kinase-F-bisphosphatase; Fru-6-P,2-kinase; Fru-kinase-Fru-bisphosphatase; Fructose 2,6-bisphosphatase; Fructose-2,6-bisphosphate 2-phosphatase; Fructose-6-P,2-kinase; Fructose-6-phosphate,2-kinase; Fructose- 6- phosphate,2- kinase- fructose- 2,6- bisphosphatase; fructose-2,6-diphosphatase; 6-Phosphofructo-2-kinase; 6- Phosphofructo- 2- kinase- fructose- 2,6- bisphosphatase; Fructose-2,6-bisphosphatase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Fructokinases
        Phosphofructokinases: 536
        Phosphofructokinase-2: 60
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Phosphofructokinase-2: 60
  - Multifunctional Enzymes: 108
    - Phosphofructokinase-2: 60

human PFKFB3 protein

Bio-Agent Context: Research Results