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cryptophycin 8
prepared by the conversion of the epoxide group on cryptophycin-1 to a chlorohydrin.
Also Known As:
cryptophycin-8
Networked:
1
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
cryptophycin 8: 1
Lactones: 1549
cryptophycin 8: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Lactams: 2198
cryptophycin 8: 1
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
Depsipeptides: 297
cryptophycin 8: 1
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
Depsipeptides: 297
cryptophycin 8: 1
Related Diseases
1.
Neoplasms (Cancer)
03/01/1996 - "
Cryptophycin-8 was less potent than cryptophycin-1 by approximately 4-fold; however, it was both more water soluble and had greater therapeutic efficacy, as demonstrated by % T/C, tumor cell log kill values, range of dose effectiveness and host cures.
"
03/01/1996 - "
In the studies reported here, cryptophycin-8 was evaluated for preclinical activity against subcutaneous tumors of both mouse and human origin.
"