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tipranavir

inhibits HIV-1 protease; structure in first source
Also Known As:
Aptivus; PNU 140690; PNU-140690; tipranavir, (R-(R*,R*))-isomer; tipranavir, (S-(R*,R*))-isomer; tipranavir, (S-(R*,S*))-isomer
Networked: 45 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Sabo, John P: 2 articles (03/2011 - 12/2005)
2. Tomillero, A: 2 articles (12/2010 - 05/2009)
3. Moral, M A: 2 articles (12/2010 - 05/2009)
4. Anta, Lourdes: 2 articles (07/2010 - 10/2009)
5. Soriano, Vincent: 2 articles (07/2010 - 10/2009)
6. Rusconi, Stefano: 2 articles (07/2009 - 03/2004)
7. Temesgen, Zelalem: 2 articles (09/2007 - 11/2005)
8. De Clercq, E: 2 articles (01/2007 - 04/2002)
9. Mauss, Stefan: 1 article (03/2011)
10. MacGregor, Thomas R: 1 article (03/2011)

Related Diseases

1. HIV Infections (HIV Infection)
2. Acquired Immunodeficiency Syndrome (AIDS)
10/01/2009 - "Three genotypic inhibitory quotients (gIQs) were calculated by using different TPV resistance mutation scores (from the International AIDS Society-USA [IAS-USA], Randomized Evaluation of Strategic Intervention in Multidrug-Resistant Patients with Tipranavir [RESIST], and Agence Nationale de Recherches sur le Sida et les Hépatites Virales [ANRS] trials). "
06/01/2008 - "The tipranavir response by FIV may 1) support the idea of using FIV as a small animal model for PI-resistant HIV-1, thus expanding access to animal AIDS models; and 2) pave the way for development of novel broad-based inhibitors for treatment of drug resistant HIV-1."
07/01/2010 - "The presence of resistance mutations in patients failing tipranavir or darunavir was examined at the national drug resistance database of the Spanish AIDS Research Network. "
07/01/2009 - "Tipranavir, a non-peptidic protease inhibitor which shows in vitro efficacy against some HIV-1-resistant strains, can be used in salvage therapies for multi-experienced HIV patients due to its peculiar resistance profile including 21 mutations at 16 protease positions according to International AIDS Society (IAS). "
01/01/2008 - "The results suggest that the two inhibitors nelfinavir and tipranavir could be used for treatment of AIDS by targeting the enzyme HIV protease as neither of the two inhibitors exhibit any cross-reactivity with other human proteins, they readily bind to the mutated enzyme active site and still remain linked with the enzyme-substrate complex in the presence of water molecules. "
3. Meningitis
4. Erectile Dysfunction
5. Infection

Related Drugs and Biologics

1. Protease Inhibitors (Protease Inhibitor)
2. Ritonavir (Norvir)
3. P-Glycoprotein
4. Serotonin Receptor Agonists (Serotonin Receptor Agonist)
5. Tryptamines (Triptans)
6. Histamine Antagonists (Antihistamines)
7. Calcium Channel Blockers (Blockers, Calcium Channel)
8. darunavir (Prezista)
9. lopinavir (Kaletra)
10. enfuvirtide (Fuzeon)

Related Therapies and Procedures

1. Salvage Therapy
2. Highly Active Antiretroviral Therapy (HAART)
3. Stents