myosin light chain 2

restricted to cardiac muscle; expression in skeletal muscle is repressed; has been sequenced; GenBank AF081462 (zebrafish)
Also Known As:
Dmlc2 protein, Drosophila; MLC2 protein; Mlc2 protein, Drosophila; Myosin light chain 2 protein, Drosophila; cardiac MLC2; mlc2f protein, zebrafish; mylz2 protein, zebrafish; myosin light chain 2 protein; myosin, light polypeptide 2, skeletal muscle protein, zebrafish
Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Cadete, Virgilio J J: 2 articles (08/2012 - 12/2010)
2. Sawicki, Grzegorz: 2 articles (08/2012 - 12/2010)
3. Sawicka, Jolanta: 2 articles (08/2012 - 12/2010)
4. Vutthasathien, Pavarana: 1 article (10/2015)
5. Wattanapermpool, Jonggonnee: 1 article (10/2015)
6. Liu, Y: 1 article (01/2014)
7. Sebti, S M: 1 article (01/2014)
8. Wang, B: 1 article (01/2014)
9. Li, R: 1 article (01/2014)
10. Patel, R A: 1 article (01/2014)

Related Diseases

1. Prostatic Neoplasms (Prostate Cancer)
2. Neoplasms (Cancer)
01/01/2007 - "We report that Smurf1-dependent RhoA degradation in tumor cells results in the down-regulation of Rho kinase (ROCK) activity and myosin light chain 2 (MLC2) phosphorylation at the cell periphery. "
12/31/2007 - "Cell motility and the disruption of epithelial architecture require a Rho kinase- and myosin light chain kinase-dependent increase in the phosphorylation of myosin light chain 2. Our results identify a new mechanism for the disruption of architecture in epithelial acini and suggest that ERK1/2 can promote noninvasive motility in preinvasive mammary tumors."
11/28/2006 - "Mass spectrometric analysis resulted in the identification of beta-tropomyosin (TMbeta), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexin I and an unknown polypeptide as the down regulated polypeptides in tumor tissue. "
12/03/2010 - "Up-regulated proteins in metastatic carcinomas included proliferating cell nuclear antigen, ferritin light chain, bomapin, tropomyosin 3, thioredoxin-containing domain C5, adenosin, ornithine aminotransferase, coronin 1A, RAN-binding protein 1,3-phosphoglycerate dehydrogenase, and eukaryotic translation elongation factor 1. Down-regulated proteins in metastatic carcinomas included calretinin, myosin, light chain 2, peroxiredoxin 6, maspin, ibrinogen beta chain, vinculin, isocitrate dehydrogenase 1, tropomyosin 1, annexin A5, and Rho GTPase activating protein 1. Interestingly, 19 of these 21 proteins have been described with a malignancy-associated expression in human breast cancer and other human cancer types before. "
3. Hypertrophy
4. Cardiomegaly (Heart Hypertrophy)
5. Chagas Disease (American Trypanosomiasis)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Messenger RNA (mRNA)
3. Osteopontin
4. Collagen Type I (Type I Collagen)
5. Myoglobin
6. Myosin Heavy Chains (Myosin Heavy Chain)
7. Troponin I
8. rho-Associated Kinases
9. Troponin T (T, Troponin)
10. Vinculin