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peroxisomal acyl-CoA oxidase

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-CH Group Donors
      - Acyl-CoA Dehydrogenases: 26
        Acyl-CoA Oxidase: 154
        peroxisomal acyl-CoA oxidase: 10
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Flavoproteins: 234
    - Acyl-CoA Oxidase: 154
      - peroxisomal acyl-CoA oxidase: 10

Experts

1.	Enokizono, Takashi: 1 article (03/2021)
2.	Iwama, Kazuhiro: 1 article (03/2021)
3.	Matsumoto, Naomichi: 1 article (03/2021)
4.	Mizuguchi, Takeshi: 1 article (03/2021)
5.	Morita, Atsushi: 1 article (03/2021)
6.	Morita, Masashi: 1 article (03/2021)
7.	Ohto, Tatsuyuki: 1 article (03/2021)
8.	Shimozawa, Nobuyuki: 1 article (03/2021)
9.	Takada, Hidetoshi: 1 article (03/2021)
10.	Takada, Yui: 1 article (03/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/23/1993 - "We suggest that the changes in peroxisomal acyl-CoA oxidase activity in hepatoma cells are due to a major effect on the level of mRNA, involving both transcriptional effects and message stabilization." 09/15/1993 - "The 3-thia fatty acid tetradecylthioacetic acid (TTA) has recently been shown to inhibit growth rate and increase peroxisomal acyl-CoA oxidase (ACO) (EC 1.3.99.3) activity in the Morris 7800 C1 hepatoma cells. " 01/23/1993 - "Induction of peroxisomal acyl-CoA oxidase by 3-thia fatty acid, in hepatoma cells and hepatocytes in culture is modified by dexamethasone and insulin." 01/23/1993 - "The effects of tetradecylthioacetic acid (TTA) (50 microM), dexamethasone (0.25 microM) and insulin (0.4 microM) on induction of peroxisomal acyl-CoA oxidase activity and mRNA levels were studied in short term cultures of Morris 7800C1 and MH1C1 hepatoma cells and of rat hepatocytes. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/14/2012 - "Of the common genetic regulators some such as chaperones, ubiquitin-related enzymes (including the E3 ligase CHIP which directly links the two pathways) and histone deacetylases were involved in expected pathways whereas others such as the peroxisomal acyl CoA-oxidase suggest novel targets for neurodegenerative disease therapy We identified a significant number of overlapping regulators of neurodegenerative disease models. "
3.	Weight Gain 05/01/2013 - "However, on the ad libitum-fed high-fat diet the L-FABP (-/-) mice exhibited: (1) decreased hepatic long chain fatty acid (LCFA) β-oxidation as indicated by lower serum β-hydroxybutyrate level; (2) decreased hepatic protein levels of key enzymes mitochondrial (rate limiting carnitine palmitoyl acyltransferase A1, CPT1A; HMG-CoA synthase) and peroxisomal (acyl CoA oxidase 1, ACOX1) LCFA β-oxidation; (3) increased fat tissue mass (FTM) and FTM/energy intake to the greatest extent; and (4) exacerbated body weight gain, weight gain/energy intake, liver weight, and liver weight/body weight to the greatest extent. "
4.	Seizures (Absence Seizure) 03/01/2021 - "Peroxisomal acyl-CoA oxidase (ACOX1) deficiency is a rare autosomal recessive single enzyme deficiency characterized by hypotonia, seizures, failure to thrive, developmental delay, and neurological regression starting from approximately 3 years of age. "
5.	Necrosis 08/01/2012 - "Increased liver weight, single-cell necrosis, cell proliferation, and peroxisomal acyl-CoA oxidase (ACO) were observed at 800 ppm after 28 days, but there was no increase in peroxisomes. "

Related Drugs and Biologics

1.	Enzymes
2.	Fatty Acids (Saturated Fatty Acids)
3.	Proteins (Proteins, Gene)
4.	1-(carboxymethylthio)tetradecane
5.	AMP-Activated Protein Kinases
6.	Adiponectin
7.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
8.	Ubiquitin
9.	Fenretinide
10.	Superoxide Dismutase

Related Therapies and Procedures

1.	Therapeutics