gp43 tumor-associated antigen

recognized by monoclonal antibody L92, associated with human melanoma; has immunoreactive tetrapeptide sequence Lys-Tyr-Gln-Ile

Also Known As:

tumor-associated antigen, gp43; 43-kDa protein, melanoma; gp43 antigen

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Antigens: 143924
  - Neoplasm Antigens: 6217
    - gp43 tumor-associated antigen: 10

Experts

1.	Lopes, José Daniel: 3 articles (03/2006 - 08/2003)
2.	Mariano, Mario: 2 articles (03/2006 - 10/2003)
3.	Belitardo, Donizeti R: 1 article (08/2013)
4.	Camargo, Zoilo P: 1 article (08/2013)
5.	Ferreira, Jacqueline B: 1 article (08/2013)
6.	Freire, Roberta L: 1 article (08/2013)
7.	Itano, Eiko N: 1 article (08/2013)
8.	Navarro, Italmar T: 1 article (08/2013)
9.	Oliveira, Gabriela G: 1 article (08/2013)
10.	Omori, Aline M: 1 article (08/2013)

Related Diseases

1.	Paracoccidioidomycosis (South American Blastomycosis) 08/01/2003 - "Detection of circulating gp43 antigen in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid of patients with paracoccidioidomycosis." 03/01/1995 - "Lack of reactivity of paracoccidioidomycosis sera in the double immunodiffusion test with the gp43 antigen: report of two cases." 08/01/2013 - "The humoral immune response to the gp43 antigen, the main antigen used for paracoccidioidomycosis serodiagnosis and seroepidemiology, was evaluated in two goats immunized with inactivated P. " 04/01/2007 - "By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM." 09/01/1991 - "Both forms are equally resistant to endogenous proteases at neutral pH. The gp43, itself, has a proteolytic activity at pH 5-6, but not at neutral pH. Deglycosylation with endoglycosidase H or tunicamycin preserved epitopes in the 38-kDa molecule reactive with (a) antibodies from patients with paracoccidioidomycosis, or rabbit immunized with the gp43 and (b) mouse monoclonal antibodies against the gp43 antigen. "
2.	Melanoma (Melanoma, Malignant) 07/01/1998 - "Augmentation of IgM antibody to gp43 tumor-associated antigen peptide by melanoma cell vaccine." 06/15/1997 - "Recognition of gp43 tumor-associated antigen peptide by both HLA-A2 restricted CTL lines and antibodies from melanoma patients." 07/01/1998 - "We previously reported that gp43 tumor-associated antigen peptide (DLTMKYQIF; designated 810 antigen) on human melanoma cells is recognized by IgM human monoclonal antibody L92 and by cytotoxic T lymphocytes (CTL). "
3.	Infections 03/01/2010 - "In order to evaluate canine infection with this fungus, a survey with 149 urban and 126 rural dogs was carried out using ELISA and intradermal tests with the gp43 antigen of P. "
4.	Hypersensitivity (Allergy) 10/01/2003 - "Immunity and hypersensitivity to gp43 antigen in susceptible and resistant mice infected with Paracoccidioides brasiliensis."
5.	Granuloma 03/01/2006 - "Granuloma formation in vitro requires B-1 cells and is modulated by Paracoccidioides brasiliensis gp43 antigen."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Antigens
3.	Monoclonal Antibodies
4.	Antibodies
5.	HLA-A2 Antigen (HLA A2 Antigen)
6.	Vaccines
7.	Tunicamycin
8.	Peptide Hydrolases (Proteases)
9.	Immunoglobulin M (IgM)
10.	Glycoside Hydrolases (Endoglycosidases)