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N-(6,7-difluoroquinolonyl)ampicillin

structure given in first source

Also Known As:

AU-1

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fujino, Tomofumi: 2 articles (01/2018 - 01/2017)
2.	Hayakawa, Makio: 2 articles (01/2018 - 01/2017)
3.	Mimaki, Yoshihiro: 2 articles (01/2018 - 01/2017)
4.	Yokosuka, Akihito: 2 articles (01/2018 - 01/2017)
5.	Ichikawa, Harutaka: 1 article (01/2018)
6.	Oshima, Toshiyuki: 1 article (01/2018)
7.	Fujiwara, Yasuyuki: 1 article (01/2017)
8.	Harashima, Wataru: 1 article (01/2017)
9.	Higurashi, Hideaki: 1 article (01/2017)
10.	Miki, Yuichi: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 10/20/2023 - "In patient-derived xenograft (PDX) models, AU-1 monotherapy exhibited remarkable tumor-inhibiting activity and is synergistic anti-tumor effects when combined with erlotinib. " 10/20/2023 - "The findings of this study illustrated that the overexpression of bromodomain PHD finger transcription factor (BPTF) is partially responsible for erlotinib resistance in GC, and the combination of the BPTF inhibitor AU-1 with erlotinib synergistically inhibited tumor growth both in vivo and in vitro. "
2.	Diarrhea 01/01/1994 - "Rotaviruses belonging to the AU-1 genogroup recovered from Israeli infants with diarrhea." 09/01/1989 - "It is of particular interest that the fourth gene of the AU-1 and AU228 strains recovered from children with diarrhea failed to hybridize to the corresponding gene of either asymptomatic or symptomatic rotavirus strains but showed a high degree of homology with the fourth gene of a feline rotavirus recovered from an apparently healthy cat. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2017 - "AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner." 01/01/2018 - "In this article, we showed that, unlike in renal adenocarcinoma cells, AU-1 does not affect the expression of SIRT1 in the normal renal cell-derived cell line HK-2. " 01/01/2017 - "In renal adenocarcinoma ACHN cells, AU-1 transiently elevated the expression level of p21/Cip1 protein without marked increases in p21/Cip1 mRNA levels. "
4.	Carcinogenesis 01/01/2018 - "Our results suggest that AU-1 may prevent carcinogenesis caused by increased cellular PGAM."
5.	Lymphoma (Lymphomas) 01/01/2014 - "No significant difference in the level of CXCR4 expression was found in reactive lymph nodes compared to lymphoma samples We observed high level of CXCR4 expression in most patients before treatment: in bone marrow: 3 AU-10 pts, 2 AU-8 pts, 1 AU-2 pts. In peripheral blood: 3 AU-14 pts, 2 AU-4 pts, 1 AU-1 pts, 0 AU-1 pts. After chemotherapy, significant decrease in CXCR4 expression was observed. "

Related Drugs and Biologics

1.	Erlotinib Hydrochloride (CP 358,774)
2.	fetal Alzheimer antigen
3.	Sirtuin 1
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)