Ro 32-3555

structure given in first source

Also Known As:

3(R)-(cyclopentylmethyl)-2(R)-((3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl)-4-oxo-4-piperidinobutyrohydroxamic acid; Ro-32-3555; Ro32-3555

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Ro 32-3555: 8

Experts

1.	Geary, Michael B: 1 article (03/2016)
2.	Hammert, Warren C: 1 article (03/2016)
3.	Loiselle, Alayna E: 1 article (03/2016)
4.	O'Keefe, Regis J: 1 article (03/2016)
5.	Orner, Caitlin A: 1 article (03/2016)
6.	Grandgirard, Denis: 1 article (04/2014)
7.	Leib, Stephen L: 1 article (04/2014)
8.	Leppert, David: 1 article (04/2014)
9.	Liechti, Fabian D: 1 article (04/2014)
10.	Breen, Ronan: 1 article (05/2011)

Related Diseases

1.	Rheumatoid Arthritis 09/01/2000 - "The past year has seen a number of disappointments with the halting of clinical trials of Ro 32-3555 in patients with rheumatoid arthritis and of BAY 12-9566 in patients with cancer. " 11/01/2001 - "Several MMP inhibitors have entered clinical trials as a result of impressive data in animal models, although only one MMP inhibitor, Ro32-3555 (Trocade), a collagenase selective inhibitor, has been fully tested in the clinic, but it did not prevent progression of joint damage in patients with rheumatoid arthritis. " 01/01/1998 - "Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis."
2.	Neoplasms (Cancer) 09/01/2000 - "The past year has seen a number of disappointments with the halting of clinical trials of Ro 32-3555 in patients with rheumatoid arthritis and of BAY 12-9566 in patients with cancer. "
3.	Cicatrix (Scar) 03/01/2016 - "The purpose of this study was to investigate whether Ro 32-3555, an Mmp9 inhibitor, can improve flexor tendon healing by limiting adhesion formation or enhancing remodeling of scar tissue during murine flexor tendon healing. "
4.	Osteoarthritis 06/01/1997 - "6. Ro 32-3555 is a potential therapy for the treatment of the chronic destruction of articulating cartilage in both rheumatoid and osteoarthritis." 09/01/1998 - "Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis."
5.	Osteophyte 09/01/1998 - "Significant inhibition of joint space narrowing and osteophyte formation was achieved in groups of animals treated with 10-50 mg/kg(-1) of Ro 32-3555. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Collagenases (Collagenase)
3.	Bay 12-9566
4.	Interleukin-1alpha (Interleukin 1 alpha)
5.	Protective Agents
6.	Interleukin-6 (Interleukin 6)
7.	Collagen
8.	2- (1- (hydroxycarbamoyl)- 4- phenyl- 3- butenyl)- 2'- isobutyl- 2'- (methanesulfonyl)- 4- methylvalerohydrazide

Related Therapies and Procedures

1.	Therapeutics