Niemann-Pick C1 Protein

A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.

Also Known As:

NPC1 Protein; Niemann Pick C1 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Niemann-Pick C1 Protein: 32
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Virus Receptors: 342
        Niemann-Pick C1 Protein: 32
      - Patched Receptors: 58
        Niemann-Pick C1 Protein: 32
    - Membrane Transport Proteins: 589
      - Niemann-Pick C1 Protein: 32
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Patched Receptors: 58
        Niemann-Pick C1 Protein: 32

mouse Npc1 protein

Bio-Agent Context: Research Results