cytotrienin A

induces apoptosis in leukemia cells; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Leukemia 11/01/1998 - "A novel anticancer drug, cytotrienin A, isolated from Streptomyces sp., induces apoptosis (or programmed cell death) in human promyelocytic leukemia HL-60 cells within 4 h. " 04/01/1997 - "Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells." 03/24/2000 - "Herein the correlation between cytotrienin A-induced apoptosis and the activation of MST/Krs proteins was examined in human tumor cell lines, including leukemia-, lung-, epidermoid-, cervix-, stomach-, and brain-derived cell lines. " 03/24/2000 - "We found that antitumor drugs such as cytotrienin A, camptothecin, taxol, and 5-fluorouracil induced the activation of a 36-kDa protein kinase (p36 myelin basic protein (MBP) kinase) during apoptosis in human promyelocytic leukemia HL-60 cells. "
2.	Carcinoma (Carcinomatosis) 09/30/2011 - "In human lung carcinoma A549 cells, cytotrienin A was found to inhibit more strongly the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor (TNF)-α than the expression induced by interleukin (IL)-1α. "

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Paclitaxel (Taxol)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Proteins (Proteins, Gene)
5.	Protein Kinases (Protein Kinase)
6.	Phosphotransferases (Kinase)
7.	Interleukins
8.	Fluorouracil (Carac)
9.	Myelin Basic Protein
10.	Camptothecin