|1.||Itoh, T: 2 articles (12/2010 - 07/2010)|
|2.||Tréguer, Karine: 1 article (09/2013)|
|3.||Mercader, Josep: 1 article (09/2013)|
|4.||Gomez-Zorita, Saioa: 1 article (09/2013)|
|5.||Carpéné, Christian: 1 article (09/2013)|
|6.||Ichii, Hirohito: 1 article (01/2012)|
|7.||Shiang, Keh-Dong: 1 article (01/2012)|
|8.||Kandeel, Fouad: 1 article (01/2012)|
|9.||Valiente, Luis: 1 article (01/2012)|
|10.||Iglesias, Itzia: 1 article (01/2012)|
05/01/2006 - "By multiple linear regression, the most significant variables that significantly improved islet yield were, firstly, the presence of <30 EU (endotoxin units) of endotoxin in Liberase batches, followed by a WIT under 10 min and the use of blood exsanguination before pancreas harvesting (P < 0.005). "
05/01/2006 - "Morphological screening of the pig pancreas before isolation, optimal blood exsanguination, WIT <10 min, and an endotoxin content <30 EU/mg in Liberase PI batches determine successful pig islet isolation for xenotransplantation in primates."
05/01/2006 - "The impact on islet yield of (1) pancreas procurement (blood exsanguination and warm ischaemia time (WIT)), (2) cold storage solutions (classic UW and modified UW (without hydroxyethyl starch and inverse K+/Na+ concentration)), (3) a dynamic or static method of pancreas digestion, and (4) the endotoxin content and enzymatic activity from five different batches of Liberase PI was studied. "
|2.||Prion Diseases (Transmissible Spongiform Encephalopathies)
12/01/2010 - "The potential for introducing transmissible spongiform encephalopathy (TSE) into islet cells was indicated by recognizing that Liberase HI is isolated from Clostridium histolyticum grown in media containing brain-heart infusion broth. "
08/15/2010 - "After the discontinuation of the manufacturing Liberase HI because of a small potential for prion disease transmission, Roche Diagnostics (Indianapolis, IN) developed a new enzyme product (Liberase MTF [mammalian tissue free]), which is similar to Liberase HI with the exception that no mammalian tissue is used in the manufacture of the collagenase component. "
|3.||Brain Death (Brain Dead)
12/01/2008 - "PPI were isolated from brain-dead hybrid pigs (age 6-7 months or 2-3 years) using the Ricordi-technique and Liberase(PI). "
07/01/2010 - "The digestion of each of 17 pancreata from brain-dead donors was performed using the following collagenases: Liberase HI (HI; Roche, n = 9); Liberase MTF C/T (MTF; Roche, n = 4); Collagenase NB1 Premium Grade (NB1; Serva, n = 7); or Clzyme Collagenase HA (CI, VitaCyte, n = 4). "
|4.||Delayed Graft Function
|1.||Heterologous Transplantation (Xenotransplantation)