|1.||Shair, Matthew D: 2 articles (05/2015 - 09/2011)|
|2.||Burgett, Anthony W G: 2 articles (10/2014 - 09/2011)|
|3.||Jin, Zhendong: 2 articles (02/2013 - 12/2005)|
|4.||Lou, Changgang: 2 articles (02/2013 - 12/2005)|
|5.||Huang, Peng: 2 articles (02/2013 - 12/2005)|
|6.||Zhou, Yan: 2 articles (02/2013 - 12/2005)|
|7.||Kang, Ying: 2 articles (02/2013 - 12/2005)|
|8.||Garcia-Prieto, Celia: 2 articles (02/2013 - 12/2005)|
|9.||Wojtkielewicz, Agnieszka: 2 articles (05/2011 - 07/2007)|
|10.||Morzycki, Jacek W: 2 articles (05/2011 - 07/2007)|
02/01/2013 - "The extremely potent activity of OSW-1 against leukemia cells and its unique mechanism of action suggest that this compound may be potentially useful in the treatment of leukemia."
02/01/2013 - "In this study, we showed that OSW-1 effectively killed leukemia cells at subnanomolar concentrations through a unique mechanism by causing a time-dependent elevation of cytosolic Ca(2+) prior to induction of apoptosis. "
02/01/2013 - "Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis."
12/07/2005 - "Clones of leukemia cells with mitochondrial DNA defects and respiration deficiency that had adapted the ability to survive in culture without mitochondrial respiration also were resistant to OSW-1. "
12/07/2005 - "In vitro analysis revealed that OSW-1 effectively killed primary leukemia cells from chronic lymphocytic leukemia patients with disease refractory to fludarabine. "
05/01/2015 - "Together, we here report the anti-enterovirus activity of the natural anti-cancer compound OSW-1. "
05/01/2015 - "Here, we investigated the antiviral activity of the natural compound OSW-1, a ligand of OSBP that is under investigation as an anti-cancer drug. "
05/12/2011 - "The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. "
07/26/2007 - "The cytotoxicity of the analogues toward several types of malignant tumor cells was examined and compared with that of OSW-1. "
12/07/2005 - "Nonmalignant cells were statistically significantly less sensitive to OSW-1 than cancer cells, with concentrations that cause a 50% loss of cell viability 40-150-fold greater than those observed in malignant cells. "
|3.||B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
12/07/2005 - "Electron microscopy and biochemical analyses revealed that OSW-1 damaged the mitochondrial membrane and cristae in both human leukemia and pancreatic cancer cells, leading to the loss of transmembrane potential, increase of cytosolic calcium, and activation of calcium-dependent apoptosis. "
|5.||Hepatocellular Carcinoma (Hepatoma)
|6.||Mitochondrial DNA (mtDNA)