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6,11- dihydro- 5- thia- 11- aza- benzo(a)- fluorene
structure given in first source
Also Known As:
PD 146176; PD-146176
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene: 2
Experts
1.
Brounts, Lionel
: 1 article (03/2006)
2.
Harms, Bruce
: 1 article (03/2006)
3.
Heise, Charles
: 1 article (03/2006)
4.
Mangino, Martin J
: 1 article (03/2006)
Related Diseases
1.
Atherosclerosis
04/01/1997 - "
5. PD 146176 was very effective in suppressing atherogenesis, especially in the aortic arch where lesion coverage diminished from 15 +/- 4 to 0% (P < 0.02); esterified cholesterol content was reduced from 2.1 +/- 0.7 to 0 micrograms mg-1 (P < 0.02) in this region.
"
04/01/1997 - "
To provide further evidence for a role of 15-LO, the effects of PD 146176 on the development of atherosclerosis in cholesterol-fed rabbits were assessed.
"
2.
Colitis
03/01/2006 - "
Finally, mice chronically treated with a putative selective 15-lipoxygenase inhibitor (PD 146176) experienced significantly worse intestinal function during experimental colitis, relative to untreated mice.
"
Related Drugs and Biologics
1.
Cholesterol
2.
Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)