03/01/1997 - "In conscious rats, oral dosing of YM430 (100 mg/kg p.o.) produced a long-lasting hypotensive effect with slight tachycardia. "
02/01/1997 - "In conscious spontaneously hypertensive rats (SHR), single oral administration of YM430 (10-100 mg/kg) produced a dose-dependent decrease in mean blood pressure (MBP) with slight reflex tachycardia. "
03/01/1997 - "In conscious dogs, YM430 (0.1-1 mg/kg, i.v.) produced dose-dependent hypotension with tachycardia. "
03/01/1997 - "YM430 also inhibited isoproterenol (0.1 micrograms/kg i.v.)-induced tachycardia. "
02/01/1997 - "In conscious normotensive dogs (NTD: 1-10 mg/kg, p.o.), YM430 decreased MBP without reflex tachycardia, and inhibited isoproterenol (ISO)-induced tachycardia in a dose-dependent manner. "
|2.||Hypotension (Low Blood Pressure)