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YM 430

structure in first source

Also Known As:

4-((-2-hydroxy-3-phenoxypropyl)amino)butyl methyl 2,6-dimethyl-(4-(m-nitrophenyl))-1,4-dihydropyridine-3,5-dicarboxylate; YM-430; YM430

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - Nifedipine: 5733
        YM 430: 3

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 03/01/1997 - "In conscious rats, oral dosing of YM430 (100 mg/kg p.o.) produced a long-lasting hypotensive effect with slight tachycardia. " 02/01/1997 - "In conscious spontaneously hypertensive rats (SHR), single oral administration of YM430 (10-100 mg/kg) produced a dose-dependent decrease in mean blood pressure (MBP) with slight reflex tachycardia. " 03/01/1997 - "In conscious dogs, YM430 (0.1-1 mg/kg, i.v.) produced dose-dependent hypotension with tachycardia. " 03/01/1997 - "YM430 also inhibited isoproterenol (0.1 micrograms/kg i.v.)-induced tachycardia. " 02/01/1997 - "In conscious normotensive dogs (NTD: 1-10 mg/kg, p.o.), YM430 decreased MBP without reflex tachycardia, and inhibited isoproterenol (ISO)-induced tachycardia in a dose-dependent manner. "
2.	Stable Angina 10/01/1997 - "5. These findings suggest that YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina."
3.	Hypotension (Low Blood Pressure) 03/01/1997 - "In conscious dogs, YM430 (0.1-1 mg/kg, i.v.) produced dose-dependent hypotension with tachycardia. "
4.	Angina Pectoris 10/01/1997 - "5. These findings suggest that YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina."

Related Drugs and Biologics

1.	Isoproterenol (Isoprenaline)
2.	Adrenergic Receptors (Adrenergic Receptor)
3.	Calcium

Related Therapies and Procedures

1.	Oral Administration