sigma-1 receptor (receptor 1, sigma)

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33 relevant articles (2 outcomes, 3 trials/studies) found for this Bio-Agent

Also Known As:

receptor 1, sigma; 28-kDa SR-BP protein, human; OPRS1 protein, human; Oprs1 protein, mouse; Oprs1 protein, rat; SR 31747A-binding protein, human; SR-BP protein, human; mSigmaR1 protein, mouse; opioid receptor, sigma 1 protein, human; opioid receptor, sigma 1 protein, rat; opioid receptor, sigma 1, mouse; sigma-1 receptors

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 56506

Membrane Proteins: 4211

Cell Surface Receptors: 633

G-Protein-Coupled Receptors: 403

Opioid Receptors: 1680

sigma Receptors: 184

sigma-1 receptor: 33

Peptide Receptors: 283

Neuropeptide Receptors: 44

Opioid Receptors: 1680

sigma Receptors: 184

sigma-1 receptor: 33

Neurotransmitter Receptors: 266

Neuropeptide Receptors: 44

Opioid Receptors: 1680

sigma Receptors: 184

sigma-1 receptor: 33

Experts

1.	Seo, H-S: 1 article (07/2008)
2.	Beitz, A J: 1 article (07/2008)
3.	Kim, H-W: 1 article (07/2008)
4.	Kim, K-W: 1 article (07/2008)
5.	Han, H-J: 1 article (07/2008)
6.	Lee, J-H: 1 article (07/2008)
7.	Kwon, Y-B: 1 article (07/2008)
8.	Yoon, S-Y: 1 article (07/2008)
9.	Roh, D-H: 1 article (07/2008)
10.	Fujisaki, Mihisa: 1 article (05/2008)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 02/01/2006 - "INTRODUCTION: Sigma-1 receptors are expressed throughout the mammalian central nervous system (CNS) and are implicated in several psychiatric disorders, including schizophrenia and depression" 01/01/2004 - "Nevertheless, the relationship of sigma-1 receptors to the underlying pathogenesis of schizophrenia is still unclear" 07/01/2007 - "Based on behavioral and pharmacological assessments, sigma-1 receptors are important in memory and cognitive processes, and are thought to be involved in specific psychiatric illnesses, including schizophrenia, depression, and drug addiction" 01/01/2004 - "sigma-1 receptor ligands have failed to improve acute psychotic symptoms of schizophrenia in clinical trials, but, interestingly, a few studies have shown an improvement in negative symptoms in schizophrenic patients" 05/15/2008 - "Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia." Get all the results and reference details, order at left...
2.	Substance-Related Disorders (Drug Abuse) 10/01/2005 - "From behavioral studies, sigma-1 receptors were shown to be involved in higher-ordered brain functions including memory and drug dependence" 08/19/2005 - "The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse." 07/01/2007 - "Based on behavioral and pharmacological assessments, sigma-1 receptors are important in memory and cognitive processes, and are thought to be involved in specific psychiatric illnesses, including schizophrenia, depression, and drug addiction" 08/01/2005 - "The interaction between cocaine, fra-2, and sigma-1 receptors involves brain regions that are established components of the neural circuit for reward, suggesting that they may contribute to the enduring changes that underlie the cellular basis of drug abuse." 08/01/2003 - "The brain sigma-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug dependence" Get all the results and reference details, order at left...
3.	Neoplasms (Cancer) 06/01/2000 - "The purpose of this study was to immunocytochemically investigate two new markers, the sigma-1 receptor and the human sterol isomerase (hSI), in comparison with a series of clinicopathological and immunocytochemical prognostic factors in a trial including 95 patients with operable primary breast cancers" 01/26/2007 - "The sigma-1 receptor is an intracellular protein characterized as a tumor biomarker whose function remains mysterious" 01/26/2007 - "Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl- channels." 07/15/2004 - "We show in this article that small molecule antagonists of the sigma-1 receptor inhibit tumor cell survival to reveal caspase-dependent apoptosis" 07/15/2004 - "Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo." Get all the results and reference details, order at left...
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2004 - "These studies indicate that sigma-1 receptor agonists may exert therapeutic effects in depression and senile dementia" 01/01/2007 - "The sigma-1 receptor (SIGMAR1) is a subtype of a nonopioid sigma receptor family and is implicated in numerous functions connected with Alzheimer's disease (AD)" Get all the results and reference details, order at left...
5.	Seizures (Seizure) 03/01/2000 - "These data further confirm the broad-spectrum anticonvulsant activity and a good safety profile of NW-1015 even in a primate model of complex partial seizures and suggest that its affinity for sigma-1 receptors is behaviorally irrelevant." 02/24/2003 - "Ligands with high affinity for sigma-1 receptors resulted, but their activity in attenuating cocaine-induced convulsions did not correlate with sigma-1 binding affinity, and may be more closely related to their sigma-2 binding affinities." 07/13/2001 - "Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation." Get all the results and reference details, order at left...
21 Diseases and 33 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Ligands
2.	Fluvoxamine (Luvox)
3.	Cocaine (Cocaine HCl)
4.	sigma Receptors (sigma Receptor)
5.	N-Methylaspartate (NMDA)
6.	Haloperidol (Haldol)
7.	carbetapentane (pentoxyverine)
8.	Chemokine Receptors
9.	Citric Acid (Citrate)
10.	Staurosporine
27 Drugs and Important Bio-Agents and 24 more articles analyzed in the Research Interface, order at left...

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