protein phosphatase 6

human serine/threonine phosphatase that is functional homologue of budding yeast Sit4p and fission yeast ppe1; GenBank X92972

Also Known As:

PPP6C protein, human; Ppp6c protein, mouse; Ppp6c protein, rat; protein phosphatase 6, catalytic subunit, human; protein phosphatase 6, catalytic subunit, mouse; protein phosphatase 6, catalytic subunit, rat

Networked: 18 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Watanabe, Toshio: 3 articles (12/2020 - 09/2015)
2.	Ohama, Takashi: 2 articles (12/2020 - 01/2019)
3.	Chiba, Natsuko: 2 articles (07/2018 - 09/2015)
4.	Inoue, Yui: 2 articles (07/2018 - 09/2015)
5.	Kakugawa, Yoichiro: 2 articles (07/2018 - 09/2015)
6.	Kurosawa, Koreyuki: 2 articles (07/2018 - 09/2015)
7.	Miura, Koh: 2 articles (07/2018 - 09/2015)
8.	Momoi, Yuki: 2 articles (07/2018 - 09/2015)
9.	Nomura, Miyuki: 2 articles (07/2018 - 09/2015)
10.	Ogoh, Honami: 2 articles (07/2018 - 09/2015)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 12/19/2022 - "Protein Phosphatase 6 down-regulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits in psoriasis, indicating that restoration of protein phosphatase 6 can be a rational strategy for psoriasis treatment. " 07/03/2015 - "NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis." 12/19/2022 - "Through the phenotypic screen, we here identify L-menthol that ameliorates psoriasis-like skin inflammation by increasing protein phosphatase 6 in keratinocytes. " 12/19/2022 - "Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis." 12/19/2022 - "Collectively, we discover a therapeutic compound, L-menthol, for psoriasis, and uncover the dysfunctional the transcription factor hairy and enhancer of split 1- immunoglobulin-binding protein 1- protein phosphatase 6 axis that contributes to psoriasis pathology by using L-menthol as a probe."
2.	Inflammation (Inflammations) 12/19/2022 - "Through the phenotypic screen, we here identify L-menthol that ameliorates psoriasis-like skin inflammation by increasing protein phosphatase 6 in keratinocytes. " 01/01/2021 - "We additionally discuss an often overlooked effect of the RAS on inflammation which is the downregulation of anti-inflammatory factors such as klotho, peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α), transient receptor potential ankyrin 1 (TRPA1), SNF-related serine/threonine-protein kinase (SNRK), serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6C) and n-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP). "
3.	Bites and Stings (Sting) 01/01/2020 - "In this study, we identified protein phosphatase 6 catalytic subunit (PPP6C) as a binding partner of Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 48 (ORF48), which is a negative regulator of the cyclic GMP-AMP synthase (cGAS)-STING pathway. "
4.	Neoplasms (Cancer) 07/01/2018 - "Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D -driven tumor promotion." 12/01/2020 - "Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6." 01/01/2017 - "We identified fiery mountain (fmt), a regulatory subunit of the protein phosphatase 6 (PP6) complex, as a tumor suppressor that synergizes with RasV12 to drive c-Jun N-terminal kinase (JNK)-dependent tumor growth and invasiveness. " 01/01/2019 - "This review presents the accumulating evidence for the roles of protein phosphatase 6 (PP6) in cell cycle, DNA damage repair, inflammatory signaling, lymphocyte development, virus infection, tumor formation/progression, cell/tissue size, and non-coding RNA-mediated regulation. " 08/15/2014 - "We obtained evidence that PME-1 could bind and regulate protein phosphatase 4 (PP4), a tumor-promoting protein, but not the related protein phosphatase 6 (PP6). "
5.	Carcinogenesis 07/01/2018 - "Here, we address the function of protein phosphatase 6 (PP6) loss on K-ras-initiated tumorigenesis in keratinocytes. " 09/01/2015 - "Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis." 08/27/2015 - "Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA." 08/27/2015 - "Somatic mutations in the gene encoding the catalytic subunit of protein phosphatase 6 (Ppp6c) have been identified in malignant melanoma and are thought to function as a driver in B-raf- or N-ras-driven tumorigenesis. "

Related Drugs and Biologics

1.	Menthol
2.	cyclic guanosine monophosphate-adenosine monophosphate
3.	Threonine (L-Threonine)
4.	Serine (L-Serine)
5.	Proteins (Proteins, Gene)
6.	Aurora Kinases
7.	JNK Mitogen-Activated Protein Kinases
8.	Peroxisome Proliferator-Activated Receptors (PPAR)
9.	Untranslated RNA (Noncoding RNA)
10.	Mitogen-Activated Protein Kinase Kinases (MEKs)