HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

macrocycle 1

structure in first source

Also Known As:

6,7-13,14-dibenzo-1,8,4,11-dioxadiazacyclotetradecane-1,5-dione; macrocycle-1

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- macrocycle 1: 2

Experts

1.	Abell, Andrew D: 1 article (01/2009)
2.	Aitken, Steven G: 1 article (01/2009)
3.	Alexander, Nathan A: 1 article (01/2009)
4.	Bickerstaffe, Roy: 1 article (01/2009)
5.	Coxon, James M: 1 article (01/2009)
6.	Jones, Matthew A: 1 article (01/2009)
7.	Lee, Hannah Y-Y: 1 article (01/2009)
8.	McNabb, Stephen B: 1 article (01/2009)
9.	Mehrtens, Janna M: 1 article (01/2009)
10.	Morton, James D: 1 article (01/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/20/2002 - "Macrocycle 1 can be generated in clinically required amounts by chemical synthesis in only 19 steps (LLS) and represents a new clinical lead for the treatment of cancer." 11/20/2002 - "Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. "
2.	Cataract (Cataracts) 01/01/2009 - "The design and elaboration of a series of macrocyclic templates that exhibit a propensity to adopt a beta-strand-like peptide-backbone conformation led to potent and selective inhibitors of calpain 2. Macrocycle 1 retarded calcium-induced opacification in an ovine-lens culture assay and is a lead compound for the development of a drug for cataract treatment. "

Related Drugs and Biologics

1.	bryostatin 1
2.	Peptides (Polypeptides)
3.	Calpain
4.	Calcium