|1.||Penido, Carmen: 2 articles (01/2015 - 09/2012)|
|2.||Ferraris, Fausto K: 2 articles (01/2015 - 09/2012)|
|3.||Blagg, Brian S J: 2 articles (03/2013 - 10/2008)|
|4.||Conte, Fernando P: 1 article (01/2015)|
|5.||Seito, Leonardo N: 1 article (01/2015)|
|6.||Thulasiram, Hirekodathakallu: 1 article (01/2015)|
|7.||Haldar, Saikat: 1 article (01/2015)|
|8.||Henriques, Maria G: 1 article (01/2015)|
|9.||Costa, Thadeu E M M: 1 article (01/2015)|
|10.||RaviKumar, Ameeta: 1 article (01/2015)|
12/01/2009 - "Furthermore, we analyzed in vitro gedunin sensitivity data, integrated with genome-wide expression data from 54 cancer cell lines in an effort to identify genes and molecular pathways that underlie the mechanism of gedunin action. "
01/01/2014 - "Gedunin, an inhibitor of heat shock protein HSP90, triggers apoptosis of tumor cells and is thus effective against malignancy. "
07/13/2012 - "Subsequent biochemical screening of 21 limonoids revealed that some of them, such as 8β-hydroxycarapin-3,8-hemiacetal and gedunin, which exhibits anti-cancer activity, inhibited SM biosynthesis and CERT-mediated extraction of Cer from membranes. "
03/08/2013 - "Cell treatment with gedunin leads to cancer cell death by apoptosis through inactivation of p23 and activation of caspase 7, which cleaves p23 at the C terminus. "
03/08/2013 - "Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis."
09/01/2012 - "Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation."
01/01/2015 - "Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. "
01/01/2015 - "Effect of gedunin on acute articular inflammation and hypernociception in mice."
09/01/2012 - "Notably, post-treatment of mice with gedunin reverted OVA-induced lung allergic inflammation by decreasing the T lymphocyte and eosinophil counts and the levels of eosinophilotactic mediators in bronchoalveolar lavage fluid. "
01/01/2015 - "Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by zymosan (500 μg/cavity; intra-articular) in C57BL/6 mice. "
|3.||Peptic Ulcer (Peptic Ulcers)
|4.||Ovarian Neoplasms (Ovarian Cancer)
12/01/2009 - "Recently, gedunin has been shown to have potential in vitro antineoplastic properties; however, its effect on ovarian cancer cells is unknown. "
12/01/2009 - "Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation."
12/01/2009 - "We conclude that gedunin has in vitro activity against ovarian cancer cells and, further, may enhance the antiproliferative effect of cisplatin. "
12/01/2009 - "In vitro treatment of ovarian cancer cell lines with gedunin alone produced up to an 80% decrease in cell proliferation (P < 0.01) and, combining gedunin with cisplatin, demonstrated up to a 47% (P < 0.01) decrease in cell proliferation compared with cisplatin treatment alone. "
12/01/2009 - "We evaluated the in vitro effect of gedunin on SKOV3, OVCAR4, and OVCAR8 ovarian cancer cell lines proliferation, alone and in the presence of cisplatin. "
|1.||Heat-Shock Proteins (Heat-Shock Protein)
|8.||Interleukin-6 (Interleukin 6)