gedunin

09/09/2022 - "This indicates the complexity of gedunin's activity against cancer cells, underscoring the value of network pharmacological techniques for the investigation of the molecular modes of drug action. "
02/14/2017 - "The anti-cancer effect of gedunin was further validated using xenograft mouse model. "
01/01/2017 - "In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells."
12/01/2009 - "Furthermore, we analyzed in vitro gedunin sensitivity data, integrated with genome-wide expression data from 54 cancer cell lines in an effort to identify genes and molecular pathways that underlie the mechanism of gedunin action. "
11/01/2022 - "Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells."

02/03/2015 - "Effect of gedunin on acute articular inflammation and hypernociception in mice."
09/01/2012 - "Notably, post-treatment of mice with gedunin reverted OVA-induced lung allergic inflammation by decreasing the T lymphocyte and eosinophil counts and the levels of eosinophilotactic mediators in bronchoalveolar lavage fluid. "
09/01/2012 - "Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation."
02/03/2015 - "Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by zymosan (500 μg/cavity; intra-articular) in C57BL/6 mice. "
02/03/2015 - "Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. "

01/01/2022 - "This article emphasizes and proves the therapeutic effectiveness of the herbal plant active ingredient Gedunin against snakebites."
01/01/2021 - "The modified gedunin in the enzyme pocket showed improved pharmacological properties for further consideration in combating snakebites."
01/01/2021 - "Therefore, it is of interest use of natural flavonoid named gedunin from the Azadirachta indica (Neem) plant species to combat snakebites. "

02/14/2017 - "Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis. "
02/14/2017 - "Anti-proliferative effect of gedunin on pancreatic cancer cells was assessed using MTS assay. "
02/14/2017 - "Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway."
02/14/2017 - "Our data further indicates that gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities. "
02/14/2017 - "Overall, our data suggests that gedunin could serve as a potent anticancer agent against pancreatic cancers."

06/01/2022 - "Use of haematological signatures in conjunction with conventional biomarkers to assess Reno-protective effects of Gedunin in diabetic nephropathy of Streptozotocin induced diabetic rats."