collapsin response mediator protein-1

from mouse; high sequence similarity to human CRMP-1; related to Unc-33 gene product from C. elegans; involved in nervous system development; amino acid sequence given in first source; GenBank U72875

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hong, Tse-Ming: 5 articles (01/2012 - 01/2003)
2.	Yang, Pan-Chyr: 5 articles (01/2012 - 01/2003)
3.	Yang, Shuenn-Chen: 4 articles (08/2011 - 01/2003)
4.	Chang, Yih-Leong: 3 articles (01/2012 - 01/2010)
5.	Pan, Szu-Hua: 3 articles (01/2012 - 01/2010)
6.	Wu, Chen-Tu: 3 articles (01/2012 - 01/2010)
7.	Wang, Wen-Lung: 2 articles (01/2012 - 08/2011)
8.	Chao, Yu-Chih: 2 articles (08/2011 - 01/2010)
9.	Chen, Hsuan-Yu: 2 articles (08/2011 - 01/2010)
10.	Chen, Jeremy J W: 2 articles (08/2011 - 06/2008)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2019 - "In this study, we found an inhibitory effect of CRMP-1 on proliferation, migration, invasion, and an enhanced effect on apoptosis in human trophoblast cell lines HTR-8/SVneo and JEG-3 by MTT assay, colony formation assay, cell viability assay, caspase 3/7 activity assay, scratch wound assay, and Matrigel Transwell assay. "
2.	Pre-Eclampsia (Preeclampsia) 01/01/2019 - "Our previous studies have demonstrated that CRMP-1 was expressed in the trophoblasts of the whole stage of pregnancy with significantly increasing expression in the placenta of early-onset preeclampsia. " 01/01/2019 - "Thus, we suggested that CRMP-1 might have implications for the pathogenesis of preeclampsia by regulating the biological behavior of trophoblast cells."
3.	Neoplasms (Cancer) 08/01/2011 - "Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). " 08/01/2011 - "The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1." 06/01/2008 - "Collapsin response mediator protein-1 (CRMP-1) controls neural development and axonal growth but also acts as a cancer invasion suppressor. " 01/01/2003 - "As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells." 08/01/2011 - "In sum, we show that LCRMP-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis and propose that this pathway may serve as a potential anticancer target."
4.	Neoplasm Metastasis (Metastasis) 01/01/2017 - "Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization." 07/01/2016 - "It has been reported that long form collapsin response mediator protein-1 (LCRMP-1) promotes the metastasis of non-small cell lung cancer. " 08/01/2011 - "In sum, we show that LCRMP-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis and propose that this pathway may serve as a potential anticancer target." 08/01/2011 - "In addition, LCRMP-1 associated with CRMP-1, which downregulated cancer cell metastasis by interrupting the association of LCRMP-1 and WAVE-1. " 01/01/2003 - "Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/01/2016 - "It has been reported that long form collapsin response mediator protein-1 (LCRMP-1) promotes the metastasis of non-small cell lung cancer. " 01/01/2010 - "Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients." 01/01/2012 - "LCRMP-1, a novel isoform of CRMP-1, can promote cancer cell migration, invasion and associate with poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). " 08/01/2011 - "Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	matrigel
3.	Protein Isoforms (Isoforms)
4.	NF-kappa B (NF-kB)
5.	Pilocarpine (Ocusert)
6.	Calpain
7.	F 4 (F-4)