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CT 2584

Also Known As:

1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine; CT-2584; CT2584

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - CT 2584: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        CT 2584: 4

Experts

1.	Bonfil, R D: 1 article (03/2001)
2.	Bursten, S: 1 article (09/2000)
3.	Finney, R E: 1 article (09/2000)
4.	Klein, P: 1 article (09/2000)
5.	Leer, L L: 1 article (09/2000)
6.	Lewis, R A: 1 article (09/2000)
7.	Nudelman, E: 1 article (09/2000)
8.	Singer, J W: 1 article (09/2000)
9.	Waggoner, D: 1 article (09/2000)
10.	Wang, N: 1 article (09/2000)

Related Diseases

1.

Neoplasms (Cancer)

09/15/2000 - "We conclude that CT-2584 effects a novel mechanism of cytotoxicity to cancer cells, involving a specific modulation of phospholipid metabolism."
11/01/1997 - "In vivo, CT-2584 significantly reduced tumor growth in SCID mice bearing Alex 0 or 0.5 xenografts as determined by serial measurements of HBsAg. "
01/01/1997 - "Lastly, we found that B/1 cells were more resistant to a novel chemotherapeutic agent CT-2584, which appears to kill tumor cells by stimulating production of reactive oxygen intermediates in mitochondria. "
09/15/2000 - "In this report, it has been demonstrated that enhanced phospholipid metabolism through PA in tumor cells can be exploited pharmacologically for development of anticancer agents, such as CT-2584, a cancer chemotherapeutic drug candidate currently in Phase II clinical trials. "
03/01/2001 - "CT-2584, an anticancer agent that inhibits phospholipid signaling, is under development by Cell Therapeutics Inc (CTI) as a potential treatment for various types of cancer. "

Related Drugs and Biologics

1.	Phospholipids (Phosphatides)
2.	Antineoplastic Agents (Antineoplastics)
3.	Rhodamine 123
4.	Xanthine
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Verapamil (Calan)
7.	Hepatitis B Surface Antigens (HBsAg)

Related Therapies and Procedures

1.	Therapeutics