DMP 777

structure given in first source

Also Known As:

1-azetidinecarboxamide, N-((1R)-1-(1,3-benzodioxol-5-yl)butyl)-3,3-diethyl-2-(4-((4-methyl-1-piperazinyl)carbonyl)phenoxy)-4-oxo-, (2S)-; 2-(4-(((4-methyl)piperazin-1-yl)carbonyl)phenoxy)-3,3-diethyl-N-(1-(3,4-methylenedioxyphenyl)butyl)-4-oxo-1-azetidinecarboxamide; DMP-777; DMP777; L 694,458; L 694458; L-694,458; L-694458; N-(1-(1,3-benzodioxol-5-yl)butyl)-3,3-diethyl-2-(4-((4-methyl-1-piperazinyl)carbonyl)phenoxy)-4-oxo-1-azetidinecarboxamide

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - DMP 777: 15
  - Azetines
    - Azetidines: 6
      - DMP 777: 15

Experts

1.	Goldenring, James R: 12 articles (01/2021 - 03/2006)
2.	Nam, Ki Taek: 5 articles (01/2021 - 05/2007)
3.	Wang, Timothy C: 3 articles (01/2020 - 04/2006)
4.	Mills, Jason C: 3 articles (01/2017 - 02/2008)
5.	Finke, Paul E: 3 articles (09/2013 - 12/2010)
6.	Nomura, Sachiyo: 3 articles (02/2008 - 03/2006)
7.	Ogawa, Masako: 3 articles (02/2008 - 03/2006)
8.	Choi, Eunyoung: 2 articles (01/2020 - 01/2020)
9.	Sousa, Josane F: 2 articles (09/2013 - 12/2010)
10.	Weis, Victoria G: 2 articles (09/2013 - 12/2010)

Related Diseases

1.	Atrophy 01/01/2020 - "Immunostaining analyses showed that Dnmt1 was up-regulated in SPEM cells as well as in chief cells before the emergence of SPEM in mouse models of acute oxyntic atrophy using either DMP-777 or L635. " 04/01/2006 - "Over the past several years, we have studied pharmacologically induced, reversible oxyntic atrophy in rodents treated with DMP-777, a drug that acts as a parietal cell secretory membrane protonophore. " 03/01/2006 - "Recently, we have reported a model for pharmacological induction of oxyntic atrophy with DMP-777. " 06/01/2000 - "We now report that rats administered high doses of DMP 777 demonstrate reversible oxyntic atrophy. " 03/01/2006 - "Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777."
2.	Metaplasia 01/01/2020 - "In mouse models, no Trop2 was observed in the normal corpus and Trop2 was not induced in acute models of metaplasia induction with either L635 or DMP-777. " 01/01/2020 - "Mice were given high-dose tamoxifen or DMP-777 or were infected with Helicobacter pylori to induce gastric metaplasia. " 12/01/2010 - "Previous investigations have shown that infection of mice with Helicobacter felis or induction of acute parietal cell loss with the drug DMP-777 leads to the emergence of a type of metaplasia designated spasmolytic polypeptide-expressing metaplasia (SPEM). " 04/01/2006 - "DMP-777 elicits a rapid loss of parietal cells followed by the emergence of foveolar hyperplasia and spasmolytic polypeptide (SP)-expressing metaplasia (SPEM). " 03/01/2006 - "DMP-777 ablates parietal cells selectively and leads to the gastric cell lineage changes including foveolar hyperplasia and spasmolytic polypeptide expressing metaplasia (SPEM). "
3.	Infections 12/01/2010 - "Taking advantage of the chief cell-restricted expression of Mist1-Cre-ER(T2), we used lineage mapping to examine whether SPEM lineages were derived from chief cells in 3 independent models of induction by DMP-777 treatment, L-635 treatment, or H felis infection. " 09/01/2013 - "To identify the commonalities and differences between phenotypic SPEM lineages, SPEM were studied from three different mouse models of parietal cell loss: with chronic inflammation with Helicobacter felis infection; with acute inflammation with L635 treatment; and without inflammation following DMP-777 treatment. " 12/01/2010 - "Previous investigations have shown that infection of mice with Helicobacter felis or induction of acute parietal cell loss with the drug DMP-777 leads to the emergence of a type of metaplasia designated spasmolytic polypeptide-expressing metaplasia (SPEM). "
4.	Hyperplasia 04/01/2006 - "DMP-777 elicits a rapid loss of parietal cells followed by the emergence of foveolar hyperplasia and spasmolytic polypeptide (SP)-expressing metaplasia (SPEM). " 03/01/2006 - "DMP-777 ablates parietal cells selectively and leads to the gastric cell lineage changes including foveolar hyperplasia and spasmolytic polypeptide expressing metaplasia (SPEM). "
5.	Chronic Obstructive Pulmonary Disease (COPD) 07/01/2002 - "In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors. "

Related Drugs and Biologics

1.	Omeprazole (Prilosec)
2.	spasmolytic polypeptide
3.	Tamoxifen
4.	Gastrins
5.	Amphiregulin
6.	Secretory Proteinase Inhibitory Proteins
7.	Transforming Growth Factor alpha (TGF-alpha)
8.	Protons (Proton)
9.	Phenobarbital (Luminal)
10.	Intrinsic Factor

Related Therapies and Procedures

1.	Therapeutics