|1.||Epifano, Francesco: 8 articles (10/2013 - 06/2006)|
|2.||Murakami, Akira: 8 articles (07/2012 - 05/2002)|
|3.||Genovese, Salvatore: 7 articles (10/2013 - 02/2010)|
|4.||Tanaka, Takuji: 6 articles (02/2010 - 08/2005)|
|5.||Iranshahi, Mehrdad: 4 articles (11/2015 - 01/2008)|
|6.||Ohigashi, Hajime: 4 articles (01/2008 - 10/2002)|
|7.||Sasaki, Takao: 3 articles (07/2013 - 08/2010)|
|8.||Curini, Massimo: 3 articles (11/2010 - 06/2006)|
|9.||Nakajima, Mitsunari: 2 articles (01/2014 - 01/2013)|
|10.||Okuyama, Satoshi: 2 articles (01/2014 - 01/2013)|
01/01/2010 - "This study suggests that the antigenotoxic property of auraptene is of great pharmacological importance and might be beneficial for cancer prevention."
03/01/2000 - "However, the groups who received a dose of 500 ppm auraptene during the initiation phase developed significantly reduced incidence of tumors (39%; P<0.05). "
03/01/2000 - "These findings suggest that dietary auraptene is effective in inhibiting the development of esophageal tumors by NMBA when given during the initiation as well as post-initiation phases, and such inhibition is related to suppression of cell proliferation in the esophageal epithelium."
11/01/2015 - "These results candidate auraptene for further studies to evaluate its biosafety and anti-cancer effects."
11/10/2015 - "To manipulate this metabolic change characteristic of aggressive tumors, we utilized the citrus extract, auraptene, known as a mitochondrial inhibitor, testing its anticancer effects against the RCC4 cell line. "
06/15/1998 - "Auraptene administration during the postinitiation phase inhibited the incidence of colon adenocarcinoma by 58% at 100 ppm (P = 0.021) and 65% at 500 ppm (P = 0.0075). "
06/15/1998 - "Auraptene feeding during the initiation phase reduced the incidence of colon adenocarcinoma by 49% at 100 ppm (P = 0.099) and 65% at 500 ppm (P = 0.0075). "
03/01/2012 - "On the other hand, very recently naturally occurring 4'- geranyloxyferulic acid and auraptene were found as novel promising agents for the treatment of colon diseases, like adenomas and adenocarcinomas. "
10/02/2006 - "We examined the efficacy of auraptene, a citrus coumarin derivative, for suppressing MMP-7 expression in the human colorectal adenocarcinoma cell line HT-29. "
06/15/2006 - "Feeding with auraptene or collinin, at both doses, significantly inhibited the occurrence of colonic adenocarcinoma. "
01/01/2014 - "Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain."
03/05/2015 - "These findings indicate that auraptene exhibits anti-inflammatory properties via inhibiting T cell proliferation and their inflammatory cytokine secretion that may mediate the interaction between T cells and autoimmune disorders, suggesting that auraptene is a potential food-derived compound with a benefit to those with abnormally over-activation T cell mediated response and chronic inflammation such as autoimmune and inflammatory diseases. "
12/01/2013 - "Poncirus trifoliate is a traditional Chinese medicinal plant used for treating inflammation-related diseases for a long time and trifoliate orange contains abundant auraptene. "
07/01/2013 - "In RAW264 macrophages, auraptene also suppressed the inflammation induced by either LPS or the conditioned medium derived from 3T3-L1 adipocytes. "
07/01/2013 - "Our findings indicate that auraptene exhibits anti-inflammatory properties by suppressing the production of inflammatory factors that mediate the interaction between adipocytes and macrophages, suggesting that auraptene is a valuable food-derived compound with a potential to attenuate chronic inflammation in adipose tissue and to improve obesity-related insulin resistance."
03/01/1998 - "Feeding of auraptene at both doses during the initiation phase caused a significant reduction in the frequency of tongue carcinoma (100 ppm auraptene, 91% reduction, P < 0.001; 500 ppm auraptene, 63% reduction, P < 0.05). "
01/01/2009 - "The effects of auraptene on cell proliferation of MCF-7 and MDA-MB-231 human breast carcinoma cells in culture was assessed by measuring metabolism of a substrate to a formazan dye. "
03/01/1998 - "When fed auraptene after 4-NQO exposure, the frequency of tongue carcinoma was also decreased (100 ppm auraptene, 100% reduction, P < 0.001; 500 ppm auraptene, 74% reduction, P < 0.01). "
03/01/1998 - "At 7 weeks of age, all animals except those treated with auraptene alone and control groups were given 4-NQO (20 ppm) in the drinking water for 8 weeks to induce tongue carcinoma. "
11/01/2015 - "Auraptene exerts cytotoxic and apoptotic effects in breast carcinoma cell line and can be considered for further mechanistic evaluations in human cancer cells. "
|5.||Periodontal Diseases (Periodontal Disease)
10/01/2013 - "In conclusion, auraptene shows promise for promoting wound healing and controlling periodontal diseases through its capacity to interfere with inflammatory mediator secretion."
10/01/2013 - "The aim of our study was to identify novel properties of auraptene with potential for managing periodontal diseases, an inflammatory disease of bacterial origin affecting the tissues surrounding and supporting the teeth. "
01/01/2012 - "By acting on multiple targets, including pathogenic bacteria, tissue-destructive enzymes, and the host inflammatory response, auraptene and lacinartin may be promising natural compounds for preventing and treating periodontal diseases."
01/01/2012 - "The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease."
|5.||5- hydroxy- 6- methoxy- 7- (3- methyl- but- 2- enyloxy)- 2H- 1- benzopyran- 2- one
|6.||Cyclooxygenase 2 (Cyclooxygenase-2)