|1.||Alessi, Dario R: 3 articles (11/2014 - 01/2009)|
|2.||Schnieke, Angelika E: 2 articles (11/2014 - 03/2013)|
|3.||Rad, Roland: 2 articles (11/2014 - 03/2013)|
|4.||Seidler, Barbara: 2 articles (11/2014 - 03/2013)|
|5.||Schneider, Günter: 2 articles (11/2014 - 03/2013)|
|6.||Eser, Stefan: 2 articles (11/2014 - 03/2013)|
|7.||Saur, Dieter: 2 articles (11/2014 - 03/2013)|
|8.||Schmid, Roland M: 2 articles (11/2014 - 03/2013)|
|9.||Klein, Sabine: 2 articles (11/2014 - 03/2013)|
|10.||Larijani, Banafshé: 2 articles (10/2014 - 01/2012)|
01/01/2015 - "The presented data, (i) shows new, stemness-promoting role of nuclear Akt/PKB kinase, (ii) it underlines the effects of nuclear Akt on cell cycle regulation, and finally (iii) it suggests new ways to study cancer stem-like cells."
10/06/2015 - "The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. "
07/01/2015 - "3-Phosphoinositide-dependent protein kinase 1 (PDK1) is centrally involved in cancer progression, including proliferation, apoptosis and invasion. "
11/01/2014 - "As a proof of concept, we performed tumor cell-autonomous and nonautonomous targeting, recapitulated hallmarks of human multistep carcinogenesis, validated genetic therapy by 3-phosphoinositide-dependent protein kinase inactivation as well as cancer cell depletion and show that mast cells in the tumor microenvironment, which had been thought to be key oncogenic players, are dispensable for tumor formation. "
08/02/2011 - "Asymmetric cancer cell division results from asymmetric suppression of AKT/PKB kinase signaling in one daughter cell during telophase of mitosis. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2009 - "A groundbreaking study by Iorns et al. published in this issue of the Biochemical Journal suggests that a signal transduction pathway controlled by PDK1 (phosphoinositide-dependent kinase 1) plays a crucial role in regulating the sensitivity of breast cancer cells to tamoxifen. "
08/01/2007 - "The Phosphatidylinositol-3-OH kinase (PI3K)/Protein kinase B (Akt/PKB) kinase signaling pathway has been implicated in altering breast cancer response to multiple therapies. "
|3.||Esophageal Neoplasms (Esophageal Cancer)
06/01/2011 - "To explore the silencing effects of RNA interference on the expression of 3-phosphoinositide-dependent protein kinase 1 (PDK1) gene, and the effects on malignant phenotypes of esophageal carcinoma EC9706 cells. "
03/01/2007 - "3-Phosphoinositide-dependent protein kinase-1/Akt signalling and inhibition in a canine prostate carcinoma cell line."
07/01/2003 - "RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1."
|5.||Prostatic Neoplasms (Prostate Cancer)
02/15/2004 - "Together, these data underscore the role of 3-phosphoinositide-dependent protein kinase-1/Akt signaling in celecoxib-mediated in vitro antiproliferative effects in prostate cancer cells."
02/15/2004 - "3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells."
08/11/2000 - "The PTEN tumor suppressor gene is frequently inactivated in human prostate cancers, particularly in more advanced cancers, suggesting that the AKT/protein kinase B (PKB) kinase, which is negatively regulated by PTEN, may be involved in human prostate cancer progression. "
|1.||Small Interfering RNA (siRNA)
|3.||Proto-Oncogene Proteins c-akt (Protein Kinase B)
|6.||Messenger RNA (mRNA)
|7.||Protein Kinases (Protein Kinase)
|10.||Insulin Receptor Substrate Proteins