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CGS 12094

prinomide metabolite; structure given in first source

Also Known As:

CGS-12094

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - CGS 12094: 1

Related Diseases

1.	Agranulocytosis (Granulocytopenia) 02/01/1997 - "Similarly prinomide, an antiinflammatory drug, was associated with a low incidence of agranulocytosis (<0.3%) in clinical trials, even though chronic toxicity studies in rodents and primates showed no evidence of agranulocytosis with either prinomide or its parahydroxy metabolite, CGS 12094. " 02/01/1997 - "Thus during conditions which lead to elevated levels of H2O2 (e.g., active inflammation), CGS 12094 is rapidly metabolized by MPO to reactive intermediates that may be related to prinomide-induced agranulocytosis." 02/01/1997 - "Activation of CGS 12094 (prinomide metabolite) to 1,4-benzoquinone by myeloperoxidase: implications for human idiosyncratic agranulocytosis."
2.	Inflammation (Inflammations) 02/01/1997 - "Thus during conditions which lead to elevated levels of H2O2 (e.g., active inflammation), CGS 12094 is rapidly metabolized by MPO to reactive intermediates that may be related to prinomide-induced agranulocytosis."

Related Drugs and Biologics

1.	prinomide
2.	Peroxidase (Myeloperoxidase)
3.	quinone (benzoquinone)