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morelloflavone

also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source

Also Known As:

fukugetin

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Biflavonoids: 102
        morelloflavone: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Biflavonoids: 102
        morelloflavone: 8

Experts

1.	Fujise, Ken: 3 articles (01/2012 - 01/2009)
2.	Pinkaew, Decha: 3 articles (01/2012 - 01/2009)
3.	Hutadilok-Towatana, Nongporn: 2 articles (01/2012 - 01/2009)
4.	Mahabusarakam, Wilawan: 2 articles (01/2012 - 01/2009)
5.	Cho, Sung Gook: 2 articles (01/2009 - 01/2009)
6.	Liu, Mingyao: 2 articles (01/2009 - 01/2009)
7.	Campos, Vinícius R: 1 article (05/2021)
8.	Menezes, José C J M D S: 1 article (05/2021)
9.	Ai, Hongyan: 1 article (11/2016)
10.	Ding, Li: 1 article (11/2016)

Related Diseases

1.	Atherosclerosis 01/01/2012 - "We fed Ldlr(-/-)Apobec1(-/-) mice with either normal chow or chow containing 0.003% morelloflavone for 8 mo and assessed the extent of atherosclerosis by the en face and cross-sectional analyses. " 01/01/2012 - "Oral, low-dose, morelloflavone therapy retards atherosclerogenesis by limiting the migration of VSMC into the intima in the mouse model of human atherosclerosis. " 01/01/2012 - "Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice."
2.	Neoplasms (Cancer) 01/15/2009 - "These findings are the first to reveal the novel functions of morelloflavone in tumor angiogenesis and its molecular basis for the anticancer action." 01/15/2009 - "In this study, we postulated that morelloflavone might have the ability to inhibit angiogenesis, the pivotal step in tumor growth, invasiveness, and metastasis. " 12/31/2022 - "The disease-preventing properties of camboginol or morelloflavone, including anti-cancer, from various parts of G. " 01/15/2009 - "To understand the underlying mechanism of morelloflavone on the inhibitory effect of tumor growth and angiogenesis, we showed that morelloflavone could inhibit the activation of both RhoA and Rac1 GTPases but have little effect on the activation of Cdc42 GTPase. " 01/15/2009 - "Furthermore, morelloflavone inhibited tumor growth and tumor angiogenesis of prostate cancer cells (PC-3) in xenograft mouse tumor model in vivo, suggesting that morelloflavone inhibited tumorigenesis by targeting angiogenesis. "
3.	Neoplasm Metastasis (Metastasis) 01/15/2009 - "In this study, we postulated that morelloflavone might have the ability to inhibit angiogenesis, the pivotal step in tumor growth, invasiveness, and metastasis. "
4.	Carcinogenesis 01/15/2009 - "Furthermore, morelloflavone inhibited tumor growth and tumor angiogenesis of prostate cancer cells (PC-3) in xenograft mouse tumor model in vivo, suggesting that morelloflavone inhibited tumorigenesis by targeting angiogenesis. "
5.	Wounds and Injuries (Trauma) 01/01/2009 - "At the cellular level, morelloflavone robustly inhibited VSMC migration as shown by both scratch wound and invasion assays. "

Related Drugs and Biologics

1.	Biflavonoids
2.	Phosphotransferases (Kinase)
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
5.	GTP Phosphohydrolases (GTPases)
6.	Venoms
7.	Peptide Hydrolases (Proteases)
8.	Flavonoids
9.	Anticoagulants
10.	tetrahydroamentoflavone

Related Therapies and Procedures

1.	Therapeutics