alcohol dehydrogenase IV

found in frogs and some mammals; catalyzes oxidation of retinol

Also Known As:

ADH4 protein, human; Adh2 protein, mouse; Adh4 protein, mouse; Adh4 protein, rat; alcohol dehydrogenase 2, mouse; alcohol dehydrogenase 4; alcohol dehydrogenase 4 (class II), pi polypeptide, human; alcohol dehydrogenase 4 (class II), pi polypeptide, mouse; alcohol dehydrogenase 4 (class II), pi polypeptide, rat

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Alcohol Dehydrogenase: 819
        alcohol dehydrogenase IV: 8

Experts

1.	Cui, Jiarui: 1 article (01/2022)
2.	Gao, Ping: 1 article (01/2022)
3.	Peng, Wei: 1 article (01/2022)
4.	Yi, Ting: 1 article (01/2022)
5.	Zhou, Mingze: 1 article (01/2022)
6.	Zhu, Tianmin: 1 article (01/2022)
7.	Gao, Huaping: 1 article (09/2017)
8.	Wang, Sulan: 1 article (09/2017)
9.	Ye, Xiang: 1 article (09/2017)
10.	Zhang, Jing: 1 article (09/2017)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2023 - "Alcohol dehydrogenase 4 is a TP53-associated gene signature for the prediction of prognosis in hepatocellular carcinoma." 11/30/2022 - "Alcohol Dehydrogenase 4 (ADH4) is a well-known prognostic protein biomarker for predicting the survival outcomes of patients with hepatocellular carcinoma whose expression is regulated by miR-664a-3p, which is upregulated in HCC. " 09/08/2017 - "The validated proteins contain the clinically used hepatocellular carcinoma (HCC) biomarker alpha-fetoprotein (AFP) and the reported biomarker candidates Heat shock protein HSP 90-beta (HSP90), fatty acid-binding protein, epidermal (FABP5) and alcohol dehydrogenase 4 (ADH4), which demonstrated the robustness of the strategy. "
2.	Cluster Headache (Cluster Headaches) 01/01/2022 - "The circadian locomotor output cycles kaput (CLOCK) gene and the alcohol dehydrogenase 4 (ADH4) gene are promising candidates for susceptibility to cluster headaches (CH). " 01/01/2010 - "Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene."
3.	Iron Overload 09/11/2015 - "The iron overload, CYP2E1 and alcohol dehydrogenase 4 overexpression promoted reactive oxygen species (ROS) production, which resulted in arachidonic and linoleic acid peroxidation and, in turn, led to malondialdehyde production and a cellular response to ROS-mediated DNA damage. "
4.	Infections 10/27/2014 - "The alcohol dehydrogenase isoenzyme alcohol dehydrogenase IV as a candidate marker of Helicobacter pylori infection."
5.	Alcoholism (Alcohol Abuse) 05/01/2005 - "Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Proteins (Proteins, Gene)
3.	Fatty Acid-Binding Proteins
4.	Linoleic Acid (Linoleate)
5.	Cytochrome P-450 CYP2E1 (CYP2E1)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Malondialdehyde (Propanedial)
8.	Isoenzymes
9.	Heat-Shock Proteins (Heat-Shock Protein)
10.	alpha-Fetoproteins (alpha-Fetoprotein)