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RU 64004

a ketolide

Also Known As:

HMR 3004; HMR-3004; RU-64004

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Erythromycin: 3910
        Ketolides: 57
        RU 64004: 11

Experts

1.	Bergeron, M G: 1 article (01/2001)
2.	Bergeron, Y: 1 article (01/2001)
3.	Duong, M: 1 article (01/2001)
4.	Simard, M: 1 article (01/2001)
5.	Berchel, M: 1 article (10/2000)
6.	Bryskier, A: 1 article (10/2000)
7.	Goh, K S: 1 article (10/2000)
8.	Rastogi, N: 1 article (10/2000)

Related Diseases

1.	Pneumonia (Pneumonitis) 01/01/2001 - "Kinetic study of the inflammatory response in Streptococcus pneumoniae experimental pneumonia treated with the ketolide HMR 3004." 12/01/1998 - "Immunomodulating effects of HMR 3004 on pulmonary inflammation caused by heat-killed Streptococcus pneumoniae in mice." 12/01/1998 - "We investigated the influence of HMR 3004, a new ketolide antibiotic, on the pulmonary inflammation induced by heat-killed fluorescein isothiocyanate-labeled Streptococcus pneumoniae. "
2.	Infections 10/01/1997 - "The results suggest that RU 64004 has potential for use in the treatment of infections caused by respiratory pathogens including multiresistant pneumococci." 10/01/1997 - "HMR 3004 may be useful for treating respiratory tract infections if sufficient concentrations can be achieved at the local sites of infection." 02/01/1997 - "RU-64004 may enhance the role of macrolide drugs in the treatment of some serious infections caused by MLS-resistant gram-positive organisms." 10/01/1997 - "The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection."
3.	Respiratory Tract Infections (Respiratory Tract Infection) 10/08/1998 - "The 11,12-substituted ketolide 61 (HMR 3004) demonstrated a potent activity against multiresistant pneumococci associated with a well-balanced activity against all bacteria involved in respiratory infections including H. " 10/01/1997 - "HMR 3004 may be useful for treating respiratory tract infections if sufficient concentrations can be achieved at the local sites of infection."
4.	Chronic Bronchitis 05/01/1999 - "The ketolide antimicrobial agents, in particular HMR 3004, antagonize the direct and polymorphonuclear leukocyte-mediated injurious effects of phospholipids on human ciliated epithelium and may have beneficial effects in inflammatory disorders of the airways, such as asthma, chronic bronchitis, diffuse panbronchiolitis and bronchiectasis."
5.	Soft Tissue Infections 05/01/1998 - "The activities of HMR 3004 and HMR 3647 and comparator agents, especially macrolides, were determined by the agar dilution method against 262 aerobic and 120 anaerobic strains isolated from skin and soft tissue infections associated with human and animal bite wounds. " 05/01/1998 - "Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and eight other antimicrobial agents against unusual aerobic and anaerobic human and animal bite pathogens isolated from skin and soft tissue infections in humans."

Related Drugs and Biologics

1.	telithromycin (Ketek)
2.	Macrolides
3.	Clarithromycin (Biaxin)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Anti-Infective Agents (Microbicides)
6.	RU 64004
7.	Atovaquone (Mepron)
8.	Ketolides
9.	Fluorescein (Funduscein)
10.	Azithromycin (Zithromax)

Related Therapies and Procedures

1.	Therapeutics