bis- valerato- oxalato- 1,2- diaminocyclohexaneplatinum

an oral prodrug for oxaliplatin; structure given in first source

Also Known As:

C5-OHP; trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)Pt(lV); trans-bis-valerato-oxalato-1R,2R-dach-Pt(IV)

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - bis-valerato-oxalato-1,2-diaminocyclohexaneplatinum: 3

Experts

1.	Eriguchi, M: 1 article (01/2001)
2.	Kidani, Y: 1 article (01/2001)
3.	Matsuzawa, A: 1 article (01/2001)
4.	Saegusa, Y: 1 article (01/2001)
5.	Takeda, Y: 1 article (01/2001)

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 01/01/2001 - "C5-OHP cured early and advanced LMFS sarcomas more frequently than CDDP. " 01/01/2001 - "A new lipophilic platinum (Pt) compound, trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)Pt(lV) (C5-OHP), was compared with cisplatin (CDDP) by intraperitoneal injection for antitumor activities against 3 different mouse models, L1210 leukemia, LMFS sarcoma with high metastatic potential and spontaneous mammary tumor. "
2.	Leukemia L1210 01/01/2001 - "C5-OHP cured both CDDP-sensitive and -resistant L1210 leukemia frequently. " 01/01/2001 - "A new lipophilic platinum (Pt) compound, trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)Pt(lV) (C5-OHP), was compared with cisplatin (CDDP) by intraperitoneal injection for antitumor activities against 3 different mouse models, L1210 leukemia, LMFS sarcoma with high metastatic potential and spontaneous mammary tumor. "
3.	Neoplasms (Cancer) 01/01/2001 - "C5-OHP manifested a curative effect against LMFS tumors by oral route. " 01/01/2001 - "C5-OHP but not CDDP could cure mammary tumors. " 01/01/2001 - "It is likely tllat C5-OHP can eradicate tumor cells more effectively than CDDP by virtue of its weaker suppressive effects on the immune system. " 01/01/1999 - "In this study, several oxaliplatin derivatives of the general formula trans-(carboxylato)chloro(1R,2R-cyclohexanediamine)(oxala to)platinum(IV) were synthesized in order to find new derivatives with greater oral activity than C5-OHP in a clinically predictive tumor model. " 01/01/1999 - "The pharmacokinetic behaviors of C5-OHP-Cl, C6-OHP-Cl and C5-OHP following a single oral administration were studied in non-tumor-bearing male BDFl mice. "
4.	Mouth Neoplasms (Oral Cancer) 05/01/1996 - "C5-OHP was considered to be a suitable candidate for the oral cancer chemotherapy agent to be developed."

Related Drugs and Biologics

1.	Oxaliplatin (Eloxatin)
2.	Platinum
3.	Cisplatin (Platino)
4.	bis(caproato)(1,2- cyclohexanediamine)(oxalato)platinum(IV)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration